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Your search keyword '"Pisani, Antonio"' showing total 8 results
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8 results on '"Pisani, Antonio"'

1. A Dual Centre Study of Pain in Parkinson’s Disease and Its Relationship with Other Non-Motor Symptoms

Author

Ghosh, Pritha, primary, Imbriani, Paola, additional, Caputi, Nicoletta, additional, Natoli, Silvia, additional, Schirinzi, Tommaso, additional, Di Lazzaro, Giulia, additional, Covington, Lindsey, additional, Sparks, Andrew D., additional, Salnikova, Yekaterina, additional, Rukavina, Katarina, additional, Ray Chaudhuri, K., additional, and Pisani, Antonio, additional

Published
2020
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2. Amyloid-β42/Neurogranin Ratio as a Potential Index for Cognitive Impairment in Parkinson’s Disease

Author

Sancesario, Giulia Maria, primary, Di Lazzaro, Giulia, additional, Alwardat, Mohammad, additional, Biticchi, Benedetta, additional, Basile, Valerio, additional, Salimei, Chiara, additional, Colona, Vito Luigi, additional, Sinibaldi Salimei, Paola, additional, Bernardini, Sergio, additional, Mercuri, Nicola Biagio, additional, Pisani, Antonio, additional, and Schirinzi, Tommaso, additional

Published
2020
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8. Amyloid-Mediated Cholinergic Dysfunction in Motor Impairment Related to Alzheimer's Disease.

Author

Bozzali, Marco, Schirinzi, Tommaso, Di Lorenzo, Francesco, Di Lazzaro, Giulia, Martorana, Alessandro, Pisani, Antonio, Mercuri, Nicola Biagio, Sancesario, Giulia Maria, Ponzo, Viviana, and Koch, Giacomo

Subjects
ALZHEIMER'S disease, AMYLOID, CHOLINERGIC receptors, FRAGILITY (Psychology), VASCULAR dementia
Abstract

Background: Although motor disturbances parallel the course of dementia, worsening both quality of life and social costs, the pathogenesis remains still unclear.Objective: Through the combination of cerebrospinal fluid (CSF) biomarkers assessment and transcranial magnetic stimulation (TMS) protocols, here we provided a cross-sectional study to understand pathogenic mechanisms of Alzheimer's disease (AD)-related early motor disturbances.Methods: The motor phenotype, as defined with Unified Parkinson's Disease Rating Scale (UPDRS) part 2-3, Rating Scale for Gait Evaluation in Cognitive Deterioration (RSEGCD) and Tinetti scale, together with CSF profile of amyloid-β 42 (Aβ42), total-tau, and phosphorylated-tau were determined in 37 AD patients and compared to 18 patients with vascular dementia (VaD). A TMS protocol of short afferent inhibition (SAI) was further applied on a subset of AD patients. Clinical, biochemical, and neurophysiological data were then compared and correlated in order to find significant associations.Results: AD patients exhibited subtle locomotor impairment and slight extrapyramidal signs. Main motor features (UPDRS part 3, RSGECD, and Tinetti scale scores) correlate with Aβ42 levels but not with t-tau and p-tau. AD patients also presented SAI impairment directly related to UPDRS part 3 score and Aβ42 levels. Motor disturbances of VaD group did not differ statistically from AD and did not correlate with CSF biomarkers.Conclusions: The association of motor disturbances with low Aβ42 CSF levels and individual SAI suggests that amyloid-mediated degeneration of cholinergic system may account for early AD-related motor impairment, providing interesting insights either for frailty stratification of patients or personalized therapies. [ABSTRACT FROM AUTHOR]

Published
2018
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