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3 results on '"Naoki Kasahata"'

1. An 85-Year Old Male with Levodopa-Responsive Parkinsonism Followed by Dementia and Supranuclear Ophthalmoplegia Caused by Alzheimer-Type Pathology without Lewy Bodies

Author

Ayako Nakamura, Hiroyuki Kato, Toshiki Uchihara, Mariko Hagiwara, and Naoki Kasahata

Subjects
Male, Pathology, medicine.medical_specialty, Autopsy, Substantia nigra, Temporal lobe, Progressive supranuclear palsy, Levodopa, Imaging, Three-Dimensional, Parkinsonian Disorders, Alzheimer Disease, Humans, Medicine, Dementia, Aged, 80 and over, Tomography, Emission-Computed, Single-Photon, business.industry, General Neuroscience, Parkinsonism, Supranuclear ophthalmoplegia, General Medicine, medicine.disease, Magnetic Resonance Imaging, nervous system diseases, Amphetamine, Psychiatry and Mental health, Clinical Psychology, Supranuclear Palsy, Progressive, Midbrain tegmentum, Radiopharmaceuticals, Geriatrics and Gerontology, business
Abstract

An 85-year-old man developed l-dopa responsive parkinsonism indistinguishable from Parkinson's disease and subsequent dementia, followed by supranuclear ophthalmoplegia and neck dorsiflexion at the terminal stage. Midbrain tegmentum and medial temporal lobe were atrophic on magnetic resonance imaging, while decreased blood flow was predominant in frontotemporal lobes, detected by 3D-SSP of 123I- IMP SPECT. Alzheimer-type pathology without Lewy body pathology was confirmed at autopsy. Substantia nigra showed mild degeneration and several neurofibrillary tangles without Lewy body pathology or progressive supranuclear palsy cytopathology. L-dopa responsive parkinsonism could be an initial manifestation of Alzheimer's disease, which should be included in the differential diagnosis.

Published
2014
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2. Limbic and Nigral Lewy Bodies and Alzheimer's Disease Pathology Mimicking Progressive Supranuclear Palsy in a 75-Year-Old Man with Preserved Cardiac Uptake of MIBG

Author

Ayako Nakamura, Naoki Kasahata, Yoshihisa Makita, Satoshi Orimo, and Toshiki Uchihara

Subjects
Male, Pathology, medicine.medical_specialty, Substantia nigra, Progressive supranuclear palsy, Diagnosis, Differential, Atrophy, Alzheimer Disease, Limbic System, medicine, Humans, Dementia, Aged, business.industry, Myocardium, General Neuroscience, Parkinsonism, Supranuclear ophthalmoplegia, General Medicine, medicine.disease, Magnetic Resonance Imaging, eye diseases, Substantia Nigra, 3-Iodobenzylguanidine, Psychiatry and Mental health, Clinical Psychology, Lewy Bodies, Supranuclear Palsy, Progressive, Midbrain tegmentum, Brainstem, Geriatrics and Gerontology, business
Abstract

A 75-year-old man developed l-dopa non-responsive parkinsonism, supranuclear ophthalmoplegia, neck dorsiflexion, and dementia. Atrophy of the midbrain tegmentum on MRI and normal myocardial uptake of MIBG led to the clinical diagnosis of progressive supranuclear palsy (PSP). Autopsy revealed depigmentation of the substantia nigra and locus ceruleus. Alzheimer's disease pathology was advanced with PSP-like neurofibrillary tangles distribution, and Lewy bodies were abundant in limbic lobe, while scarce in lower brainstem nuclei. Tuft-shaped astrocytes were not apparent. Although decreased myocardial uptake of MIBG is a rule in patients harboring Lewy bodies, its normal uptake may be related to their absence in lower brainstem nuclei.

Published
2012
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3. Three-Repeat Tau with Grain-Like Structures and Distribution in an 83-Year-Old Man.

Author

Naoki Kasahata, Tomohide Sato, Iichiroh Onishi, Masanobu Kitagawa, Toshiki Uchihara, Katsuiku Hirokawa, Kasahata, Naoki, Sato, Tomohide, Onishi, Iichiroh, Kitagawa, Masanobu, Uchihara, Toshiki, and Hirokawa, Katsuiku

Subjects
*BRAIN diseases, *BRAIN damage, *AMYGDALOID body, *ASTROCYTES, *MORPHOLOGY, *BRAIN, *DISEASE complications, *NERVE tissue proteins, *NEURODEGENERATION, *TREATMENT effectiveness, BRAIN metabolism
Abstract

We encountered an 83-year-old man with 3-repeat dominant grain-like tau deposition. Tau-positive lesions exhibited apparent similarity to argyrophilic grains in terms of their distribution in the ambient gyrus, amygdala, and dorsomedial temporal tip and the characteristic comma-like morphology. The abundant oligodendroglial tau immunoreactivities were 3-repeat dominant. Tuft-shaped astrocytes showed partial 3-repeat tau immnoreactivities. These grain-like structures, as well as tuft-shaped astrocytes and oligodendroglia, exhibited predominant 3-repeat tau immunoreactivity, suggesting that grain-like structures and their characteristic distribution are mutually linked and not unique to 4-repeat tau deposition. pTDP immunoreactivity, extensive macrophage infiltration, and spongiosis were associated with these 3-repeat tau deposits. [ABSTRACT FROM AUTHOR]

Published
2017
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