1. Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer’s Disease: Clinical and FDG-PET Correlation
- Author
-
Vanesa Pytel, María Nieves Cabrera-Martín, Carmen Garrido, Teresa Moreno-Ramos, Marine Cordonnier, Jessica Gobbo, Gaëtan Chanteloup, Jordi A. Matías-Guiu, Ulises Gómez-Pinedo, and Jorge Matías-Guiu
- Subjects
Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Disease ,Neuropsychological Tests ,Exosomes ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Fluorodeoxyglucose F18 ,Internal medicine ,mental disorders ,medicine ,Humans ,HSP70 Heat-Shock Proteins ,Correlation of Data ,Aged ,business.industry ,General Neuroscience ,Neurodegeneration ,General Medicine ,medicine.disease ,Microvesicles ,Hsp70 ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Frontotemporal Dementia ,Positron-Emission Tomography ,Cohort ,Female ,Radiopharmaceuticals ,Geriatrics and Gerontology ,business ,Biomarkers ,030217 neurology & neurosurgery ,Frontotemporal dementia - Abstract
We aimed to study the expression of circulating heat-shock protein HSP70 and exosomes in plasma of a cohort of patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) at different stages. We performed correlations with clinical scales and FDG-PET. HSP70 levels were higher within exosomes than free in plasma. Moderate correlations were found between exosomal HSP70 and CDR, FTLD-CDR, and extension of hypometabolism. Our results suggest modifications in the level of exosomal HSP70 during the course of neurodegeneration, regardless of AD or FTD, and therefore HSP70 could have a potential role in the follow-up of these disorders.
- Published
- 2019
- Full Text
- View/download PDF