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The present investigation deals with an application of integrated sequential oxic and anoxic bioreactor (SOABR) and fluidized immobilized cell carbon oxidation (FICCO) reactor for the treatment of domestic wastewater with minimum sludge generation. The performance of integrated SOABR-FICCO system was evaluated on treating the domestic wastewater at hydraulic retention time (HRT) of 3hr and 6hr for 120days at organic loading rate (OLR) of 191±31mg/(L·hr). The influent wastewater was characterized by chemical oxygen demand (COD) 573±93mg/L; biochemical oxygen demand (BOD 5 ) 197±35mg/L and total suspended solids (TSS) 450±136mg/L. The integrated SOABR-FICCO reactors have established a significant removal of COD by 94%±1%, BOD 5 by 95%±0.6% and TSS by 95%±4% with treated domestic wastewater characteristics COD 33±5mg/L; BOD 5 9±0.8mg/L and TSS 17±9mg/L under continuous mode of operation for 120days. The mass of dry sludge generated from SOABR-FICCO system was 22.9g/m 3 . The sludge volume index of sludge formed in the SOABR reactor was 32mL/g and in FICCO reactor it was 46mL/g. The sludge formed in SOABR and FICCO reactor was characterized by TGA, DSC and SEM analysis. Overall, the results demonstrated that the integrated SOABR-FICCO reactors substantially removed the pollution parameters from domestic wastewater with minimum sludge production., (Copyright © 2017. Published by Elsevier B.V.)