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Due to the strict personnel control measures in COVID-19 epidemic, the control system cannot be maintained and managed manually. This puts forward higher requirements for the accuracy of its fault-tolerant performance. The control system plays an increasingly important role in the rapid development of industrial production. When the sensor in the system fails, the system will become unstable. Therefore, it is necessary to accurately and quickly diagnose the faults of the system sensors and maintain the system in time. This paper takes the control system as the object to carry out the fault diagnosis and fault-tolerant control research of its sensors. A network model of wavelet neural network is proposed, and an improved genetic algorithm is used to optimize the weights and thresholds of the neural network model to avoid the deficiencies of traditional neural network algorithms. For the depth sensor of a certain system, an online fault diagnosis scheme based on RBF (Radial Basis Function) neural network and genetic algorithm optimized neural network was designed. The disturbance fault, "stuck" fault, drift fault and oscillation fault of the depth sensor are simulated. Simulation experiments show that both online fault diagnosis schemes can accurately identify sensor faults and the genetic algorithm optimized neural network is superior to RBF neural network in both recognition accuracy and training time under the influence of COVID-19. [ABSTRACT FROM AUTHOR]