26 results on '"Hernández, Isabel"'
Search Results
2. Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype
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Espinosa, Ana, Alegret, Montserrat, Pesini, Pedro, Valero Ventura, Sergi, Lafuente, Asunción, Buendía, Mar, San José, Itziar, Ibarria, Marta, Tejero, Miguel Ángel, Giménez Ruiz, Joan, Ruiz, Susana, Hernández, Isabel, Pujadas, Francesc, Martínez Lage, Pablo, Munuera, Josep, Arbizu, Javier, Tárraga, Lluís, Hendrix, Suzanne B., Ruiz, Agustín, Becker, James T., Landau, Susan M., Sotolongo Grau, Oscar, Sarasa, Manuel, Boada, Mercè, and Universitat Autònoma de Barcelona
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0301 basic medicine ,cognition ,Male ,positron emission tomography ,hippocampus ,Neuropsychological Tests ,Hippocampus ,memory ,Cognition ,0302 clinical medicine ,Hippocampus (mythology) ,magnetic resonance imaging ,Neuropsychological assessment ,Composite material ,Aged, 80 and over ,Aniline Compounds ,medicine.diagnostic_test ,General Neuroscience ,amyloid ,Brain ,General Medicine ,Organ Size ,Alzheimer's disease ,3. Good health ,Psychiatry and Mental health ,Clinical Psychology ,Female ,Psychology ,Alzheimer’s disease ,Research Article ,Amyloid ,Positron emission tomography ,Prodromal Symptoms ,Neuroimaging ,03 medical and health sciences ,amnestic mild cognitive impairment ,Magnetic resonance imaging ,Memory ,Alzheimer Disease ,Fluorodeoxyglucose F18 ,mental disorders ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Survival analysis ,Aged ,medicine.disease ,Survival Analysis ,Thiazoles ,030104 developmental biology ,Positron-Emission Tomography ,Mental Recall ,Amnestic mild cognitive impairment ,Geriatrics and Gerontology ,Radiopharmaceuticals ,030217 neurology & neurosurgery - Abstract
The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8.5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. The aim of this study was to find the optimized cognitive composites (CCs) domain scores most related to neuroimaging biomarkers within Pr-aMCI-storage subtype patients. The Fundació ACE (ACE) study with 20 Pr-aMCI-storage subtype subjects (MCI) were analyzed. All subjects underwent a neuropsychological assessment, a structural MRI, FDG-PET, and PIB-PET. The adjusted hippocampal volume (aHV) on MRI, the standard uptake value ratio (SUVR) on FDG-PET and PIB-PET SUVR measures were analyzed. The construction of the CCs domain scores, and the aHV on MRI and FDG-PET SUVR measures, were replicated in the parental AB255 study database (n = 133 MCI). Partial correlations adjusted by age, gender, and education were calculated with the associated p -value among every CC domain score and the neuroimaging biomarkers. The results were replicated in the "MCI due to AD" with memory storage impairments from ADNI. Delayed Recall CC domain score was significantly correlated with PIB-PET SUVR (β= -0.61, p = 0.003) in the ACE study and also with aHV on MRI (β= 0.27, p = 0.01) and FDG-PET SUVR (β= 0.27, p = 0.01) in the AB255 study. After a median survival time of 20.6 months, 85% from the ACE MCI converted to AD. The replication of our results in the ADNI dataset also confirmed our findings. Delayed Recall is the CC domain score best correlated with neuroimaging biomarkers associated with prodromal AD diagnosis.
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- 2017
3. Dementia Care in Times of COVID-19: Experience at Fundació ACE in Barcelona, Spain.
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Benaque, Alba, Gurruchaga, Miren Jone, Abdelnour, Carla, Hernández, Isabel, Cañabate, Pilar, Alegret, Montserrat, Rodríguez, Isabel, Rosende-Roca, Maitee, Tartari, Juan Pablo, Esteban, Ester, López, Rogelio, Gil, Silvia, Vargas, Liliana, Mauleón, Ana, Espinosa, Ana, Ortega, Gemma, Sanabria, Angela, Pérez, Alba, Alarcón, Emilio, and González-Pérez, Antonio
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COVID-19 ,COVID-19 pandemic ,MILD cognitive impairment ,PATIENT safety ,DEMENTIA ,CORONAVIRUS disease treatment ,TREATMENT of dementia ,VIRAL pneumonia ,RESEARCH ,RESEARCH methodology ,PATIENT-centered care ,EVALUATION research ,MEDICAL cooperation ,HOLISTIC medicine ,COMPARATIVE studies ,EPIDEMICS ,TELEMEDICINE ,LONGITUDINAL method - Abstract
Background: Fundació ACE is a non-profit organization providing care based on a holistic model to persons with cognitive disorders and their families for 25 years in Barcelona, Spain. Delivering care to this vulnerable population amidst the COVID-19 pandemic has represented a major challenge to our institution.Objective: To share our experience in adapting our model of care to the new situation to ensure continuity of care.Methods: We detail the sequence of events and the actions taken within Fundació ACE to swiftly adapt our face-to-face model of care to one based on telemedicine consultations. We characterize individuals under follow-up by the Memory Unit from 2017 to 2019 and compare the number of weekly visits in 2020 performed before and after the lockdown was imposed.Results: The total number of individuals being actively followed by Fundació ACE Memory Unit grew from 6,928 in 2017 to 8,147 in 2019. Among those newly diagnosed in 2019, most patients had mild cognitive impairment or mild dementia (42% and 25%, respectively). Weekly visits dropped by 60% following the suspension of face-to-face activity. However, by April 24 we were able to perform 78% of the visits we averaged in the weeks before confinement began.Discussion: We have shown that Fundació ACE model of care has been able to successfully adapt to a health and social critical situation as COVID-19 pandemic. Overall, we were able to guarantee the continuity of care while preserving the safety of patients, families, and professionals. We also seized the opportunity to improve our model of care. [ABSTRACT FROM AUTHOR]- Published
- 2020
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4. The Role of Verb Fluency in the Detection of Early Cognitive Impairment in Alzheimer’s Disease
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Alegret, Montserrat, primary, Peretó, Mar, additional, Pérez, Alba, additional, Valero, Sergi, additional, Espinosa, Ana, additional, Ortega, Gemma, additional, Hernández, Isabel, additional, Mauleón, Ana, additional, Rosende-Roca, Maitée, additional, Vargas, Liliana, additional, Rodríguez-Gómez, Octavio, additional, Abdelnour, Carla, additional, Berthier, Marcelo L., additional, Bak, Thomas H., additional, Ruíz, Agustín, additional, Tárraga, Lluís, additional, and Boada, Mercè, additional
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- 2018
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5. Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer’s Disease Patients Treated with Plasma Exchange with 5% Human Albumin
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Cuberas-Borrós, Gemma, primary, Roca, Isabel, additional, Boada, Mercè, additional, Tárraga, Lluís, additional, Hernández, Isabel, additional, Buendia, Mar, additional, Rubio, Lourdes, additional, Torres, Gustavo, additional, Bittini, Ángel, additional, Guzmán-de-Villoria, Juan A., additional, Pujadas, Francesc, additional, Torres, Mireia, additional, Núñez, Laura, additional, Castell, Joan, additional, and Páez, Antonio, additional
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- 2017
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6. Social Representation of Dementia: An Analysis of 5,792 Consecutive Cases Evaluated in a Memory Clinic
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Cañabate, Pilar, primary, Martínez, Gabriel, additional, Rosende-Roca, Maitée, additional, Moreno, Mariola, additional, Preckler, Silvia, additional, Valero, Sergi, additional, Sotolongo, Oscar, additional, Hernández, Isabel, additional, Alegret, Montserrat, additional, Ortega, Gemma, additional, Espinosa, Ana, additional, Mauleón, Ana, additional, Vargas, Liliana, additional, Rodríguez, Octavio, additional, Abdelnour, Carla, additional, Sánchez, Domingo, additional, Martín, Elvira, additional, Ruiz, Agustín, additional, Tárraga, Lluís, additional, and Boada, Mercè, additional
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- 2017
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7. Impact of Recruitment Methods in Subjective Cognitive Decline
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Abdelnour, Carla, primary, Rodríguez-Gómez, Octavio, additional, Alegret, Montserrat, additional, Valero, Sergi, additional, Moreno-Grau, Sonia, additional, Sanabria, Ángela, additional, Hernández, Isabel, additional, Rosende-Roca, Maitee, additional, Vargas, Liliana, additional, Mauleón, Ana, additional, Sánchez, Domingo, additional, Espinosa, Ana, additional, Ortega, Gemma, additional, Pérez-Cordón, Alba, additional, Diego, Susana, additional, Gailhajanet, Anna, additional, Guitart, Marina, additional, Sotolongo-Grau, Óscar, additional, Ruiz, Agustín, additional, Tárraga, Lluís, additional, and Boada, Mercè, additional
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- 2017
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8. Efficacy and Safety of Plasma Exchange with 5% Albumin to Modify Cerebrospinal Fluid and Plasma Amyloid-β Concentrations and Cognition Outcomes in Alzheimer’s Disease Patients: A Multicenter, Randomized, Controlled Clinical Trial
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Boada, Mercè, primary, Anaya, Fernando, additional, Ortiz, Pilar, additional, Olazarán, Javier, additional, Shua-Haim, Joshua R., additional, Obisesan, Thomas O., additional, Hernández, Isabel, additional, Muñoz, Joan, additional, Buendia, Mar, additional, Alegret, Montserrat, additional, Lafuente, Asunción, additional, Tárraga, Lluís, additional, Núñez, Laura, additional, Torres, Mireia, additional, Grifols, Joan Ramon, additional, Ferrer, Isidre, additional, Lopez, Oscar L., additional, and Páez, Antonio, additional
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- 2017
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9. MAPT H1 haplotype is associated with late-onset Alzheimer's disease risk in APOE ε 4 noncarriers: Results from the dementia genetics Spanish consortium
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Pastor, Pau, Moreno, Fermín, Antonell, Anna, Elcoroaristizabal, Xabier, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, Belbin, Olivia, Alcolea, Daniel, Carmona-Iragui, María, Sánchez-Saudinós, M Belén, Sala, Isabel, Anton-Aguirre, Sofía, Coto, Eliecer, Morenas, Estrella, Ribosa, Roser, Colom-Cadena, Martí, Cervera, Laura, Muñoz, Laia, Dols-Icardo, Oriol, Clarimón, Jordi, Ortega-Cubero, Sara, Hernandez, Isabel, Tárraga, Lluís, Boada, Mercè, Kulisevsky, Jaime, Vázquez-Higuera, José Luis, Infante, Jon, Rábano, Alberto, Fernández-Blázquez, Miguel Ángel, Valentí, Meritxell, Indakoetxea, Begoña, Barandiarán, Myriam, Gorostidi, Ana, Frank-García, Ana, Sastre, Isabel, Lorenzo, Elena, Ruiz, Agustín, Pastor, María A, Lennarz, Martina, Maier, Wolfgang, Rámirez, Alfredo, Serrano-Ríos, Manuel, Lee, Suzee E, Sánchez-Juan, Pascual, Consortium, Dementia Genetic Spanish, Combarros, Onofre, Lorenzo-Betancor, Oswaldo, Pastor, Maria A, Hernández, Isabel, Lafuente, Asunción, Rosende-Roca, Maitée, Mauleón, Ana, Vargas, Liliana, Rodríguez, Octavio, Calero, Miguel, Abdelnour, Carla, Alegret, Montserrat, Espinosa, Ana, Ortega, Gemma, Sanabria, Ángela, Ibarria, Marta, Diego, Susana, Canyabate, Pilar, Moreno, Mariola, Buendía, Mar, López de Munain, Adolfo, Pancho, Ana, Palacio, María Eugenia, Ruiz, Susana, Tantinya, Natalia, Tarragona, Marina, Morera, América, Guitart, Marina, Sotolongo Grau, Oscar, Martín, Elvira, Fernández, Victòria, Bullido, Maria J, Sánchez-Valle, Raquel, Molinuevo, José Luis, Lladó, Albert, Rami, Lorena, Alvarez, Victoria, de Pancorbo, Marian M, Pozueta, Ana, González Suarez, Andrea, Carro, Eva, Rodriguez-Rodriguez, Eloy, Mateo, Ignacio, Berciano, José, Bullido, María J, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Universidad Pública de Navarra, Universidad del País Vasco, Universidad Autónoma de Madrid, Fundació ACE. Institut Català de Neurociències Aplicades, University of Bonn, University of California, Universitat de Barcelona, Universitat Autònoma de Barcelona, and Universitat Oberta de Catalunya (UOC)
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Gerontology ,Male ,associació genètica ,genetic association ,Apolipoprotein E4 ,A152T ,enfermedad de Alzheimer ,genetics [Alzheimer Disease] ,frontotemporal dementia ,MAPT ,Alzheimer, Enfermedad de ,genetics [Genetic Predisposition to Disease] ,genetics [Frontotemporal Dementia] ,genetics [Apolipoprotein E4] ,Aged, 80 and over ,General Neuroscience ,General Medicine ,demencia frontotemporal ,Middle Aged ,Alzheimer's disease ,Psychiatry and Mental health ,Clinical Psychology ,demència frontotemporal ,genetics [Polymorphism, Single Nucleotide] ,Christian ministry ,Female ,Alzheimer’s disease ,Frontotemporal dementia ,Late onset ,MAPT protein, human ,tau Proteins ,Polymorphism, Single Nucleotide ,asociación genética ,Alzheimer Disease ,malaltia d'Alzheimer ,mental disorders ,medicine ,Dementia ,Humans ,Genetic Predisposition to Disease ,ddc:610 ,Genetic association ,Aged ,business.industry ,Haplotype ,medicine.disease ,nervous system diseases ,H1H2 ,genetics [tau Proteins] ,Alzheimer, Malaltia d' ,Logistic Models ,Haplotypes ,Spain ,Disease risk ,Geriatrics and Gerontology ,business - Abstract
The MAPT H1 haplotype has been linked to several disorders, but its relationship with Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p.A152T) has been linked with frontotemporal dementia (FTD) and AD. We genotyped H1/H2 and p.A152T MAPT in 11,572 subjects from Spain (4,327 AD, 563 FTD, 648 Parkinson's disease (PD), 84 progressive supranuclear palsy (PSP), and 5,950 healthy controls). Additionally, we included 101 individuals from 21 families with genetic FTD. MAPT p.A152T was borderline significantly associated with FTD [odds ratio (OR)=2.03; p=0.063], but not with AD. MAPT H1 haplotype was associated with AD risk (OR=1.12; p=0.0005). Stratification analysis showed that this association was mainly driven by APOE ε4 noncarriers (OR=1.14; p=0.0025). MAPT H1 was also associated with risk for PD (OR=1.30; p=0.0003) and PSP (OR=3.18; p=8.59 × 10-8) but not FTD. Our results suggest that the MAPT H1 haplotype increases the risk of PD, PSP, and non-APOE ε4 AD., Spanish Ministry of Science and Innovation SAF 2006-10126 (2006–2009) and SAF2010-22329-C02-01 (2011–2013) to P.P and by the UTE project FIMA to P.P. Grants from the Ministry of Science (SAF2010-15558) and CIBERNED. Agust´ın Ruiz is supported by grant PI13/02434 (Acción Estratégica en Salud. Instituto de Salud Carlos III. Ministerio de Economía y Competitividad, Spain). Grant: Consolider (CSD2010-00045).
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- 2015
10. Concordance between Subjective and Objective Memory Impairment in Volunteer Subjects
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Alegret, Montserrat, primary, Rodríguez, Octavio, additional, Espinosa, Ana, additional, Ortega, Gemma, additional, Sanabria, Angela, additional, Valero, Sergi, additional, Hernández, Isabel, additional, Rosende-Roca, Maitée, additional, Vargas, Liliana, additional, Abdelnour, Carla, additional, Mauleón, Ana, additional, Gailhajanet, Anna, additional, Martín, Elvira, additional, Tárraga, Lluís, additional, Rentz, Dorene M., additional, Amariglio, Rebecca E., additional, Ruíz, Agustín, additional, and Boada, Mercè, additional
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- 2015
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11. Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin.
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Cuberas-Borrós, Gemma, Roca, Isabel, Boada, Mercè, Tárraga, Lluís, Hernández, Isabel, Buendia, Mar, Rubio, Lourdes, Torres, Gustavo, Bittini, Ángel, Guzmán-de-Villoria, Juan A., Pujadas, Francesc, Torres, Mireia, Núñez, Laura, Castell, Joan, and Páez, Antonio
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MAGNETIC resonance imaging ,ALZHEIMER'S disease ,CEREBROVASCULAR disease ,BRAIN tumors ,BRAIN injuries ,ALBUMINS - Abstract
Background: Recently, modifications of Aβ1-42 levels in CSF and plasma associated with improvement in memory and language functions have been observed in patients with mild-moderate Alzheimer's disease (AD) treated with plasma exchange (PE) with albumin replacement.Objective: To detect structural and functional brain changes in PE-treated AD patients as part of a Phase II clinical trial.Methods: Patients received between 3 and 18 PE with albumin (Albutein® 5%, Grifols) or sham-PE (controls) for 21 weeks (divided in one intensive and two maintenance periods) followed by 6-month follow-up. Brain perfusion assessed by SPECT scans using an automated software (NeuroGam®) and brain structural changes assessed by MRI were performed at weeks 0 (baseline), 21, and 44 (with additional SPECT at weeks 9 and 33). Statistical parametric mapping (voxel-based analysis, SPM) and Z-scores calculations were applied to investigate changes to baseline.Results: 42 patients were recruited (39 evaluable; 37 analyzed: 18 PE-treated; 19 controls). There was a trend toward decreasing hippocampi and total intracranial volume for both patient groups during the study (p < 0.05). After six months, PE-treated patients had less cerebral perfusion loss than controls in frontal, temporal, and parietal areas, and perfusion stabilization in Brodmann area BA38-R during the PE-treatment period (p < 0.05). SPM analysis showed stabilization or absence of progression of perfusion loss in PE-treated patients until week 21, not observed in controls.Conclusions: Mild-moderate AD patients showed decreased brain volume and impairment of brain perfusion as expected for the progression of the disease. PE-treatment with albumin replacement favored the stabilization of perfusion. [ABSTRACT FROM AUTHOR]- Published
- 2018
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12. Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease
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Moreno-Grau, Sonia, primary, Barneda, Bruna, additional, Carriba, Paulina, additional, Marín, Juan, additional, Sotolongo-Grau, Oscar, additional, Hernández, Isabel, additional, Rosende-Roca, Maitée, additional, Mauleón, Ana, additional, Vargas, Liliana, additional, Espinosa, Ana, additional, Alegret, Montserrat, additional, Rodriguez, Octavio, additional, Ortega, Gemma, additional, Fernández, Maria Victoria, additional, López-Arrieta, Jesús, additional, Tárraga, Lluís, additional, Boada, Mercè, additional, Antúnez, Carmen, additional, López, Joaquin, additional, Ruiz, Agustín, additional, and Comella, Joan Xavier, additional
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- 2015
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13. Association of TMEM106B rs1990622 Marker and Frontotemporal Dementia: Evidence for a Recessive Effect and Meta-Analysis
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Hernández, Isabel, primary, Rosende-Roca, Maitée, additional, Alegret, Montserrat, additional, Mauleón, Ana, additional, Espinosa, Ana, additional, Vargas, Liliana, additional, Sotolongo-Grau, Oscar, additional, Tárraga, Lluís, additional, Boada, Mercè, additional, and Ruiz, Agustín, additional
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- 2014
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14. Cognitive, Genetic, and Brain Perfusion Factors Associated with Four Year Incidence of Alzheimer's Disease from Mild Cognitive Impairment
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Alegret, Montserrat, primary, Cuberas-Borrós, Gemma, additional, Espinosa, Ana, additional, Valero, Sergi, additional, Hernández, Isabel, additional, Ruíz, Agustín, additional, Becker, James T., additional, Rosende-Roca, Maitée, additional, Mauleón, Ana, additional, Sotolongo, Oscar, additional, Castell-Conesa, Joan, additional, Roca, Isabel, additional, Tárraga, Lluís, additional, and Boada, Mercè, additional
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- 2014
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15. Ubiquitin-negative mini-pick like bodies in the dentate gyrus of p30l tauopathy
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Ferrer, Isidro (Ferrer Abizanda), Hernández, Isabel, Puig, Berta, Rey, María Jesús, Ezquerra, Mario, Tolosa, Eduardo, and Boada, Mercè
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Metabolism ,Ubiquitin ,Lòbul frontal ,Frontal lobe ,Malalties de Niemann-Pick ,Gene expression ,Niemann-Pick diseases ,Lòbul temporal ,Ubiqüitina ,Expressió gènica ,Metabolisme ,Temporal lobe - Abstract
Neuropathological and biochemical findings are reported in a patient who had suffered from frontotemporal dementia associated with a P310L mutation in the tau gene and included in the H1 haplotype. Tau accumulation, as revealed with phospho-specific anti-tau antibodies Thr181, Ser199, Ser202, Ser214, Ser262, Ser396, Ser422 and AT8 (Ser202 and Thr205), was found in neurons with pre-tangles, and astrocytes and oligodendrocytes through the brain. The most characteristic feature was tau immunoreactivity decorating the perinuclear region and small cytoplasmic aggregates designed as mini-Pick-like bodies, mainly in the dentate gyrus. Inclusions were not stained with anti-ubiquitin antibodies and did not recruit tubulins. Tau accumulation in individual cells was associated with increased expression of kinases linked with tau phosphorylation, mainly active (phosphorylated) stress kinases SAPK/JNK and p38 (SAPK/JNK-P and p38-P). Phosphorylated GSK-3 beta at Ser9 (GSK-3 beta-P), that inactivates the kinase, was particularly abundant in mini-Pick-like bodies, thus suggesting alternative roles of GSK-3 probably involved in cell survival. Western blots of sarkosyl-insoluble fractions revealed a double band pattern of phospho-tau of 68/66 kDa and 64 kDa in the hippocampus and white matter in the P310L mutation. Sarkosyl-insoluble fractions of the hippocampus were enriched in p38-P and GSK-3 beta-P in Alzheimer's disease (AD) cases, processed in parallel for comparative purposes, but not in the P310L mutation. In addition, no bands of high molecular weight were found in P310L in contrast with AD in these fractions. These findings indicate that the major sites of tau phosphorylation, and the expression of kinases involved in tau phosphorylation are active in P310L mutation as in AD and other tauopathies. Yet the P310L mutation has particular phospho-tau inclusions that are not tag with ubiquitin and appear to be rather soluble when compared with AD.
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- 2003
16. A Longitudinal Follow-Up of 550 Mild Cognitive Impairment Patients: Evidence for Large Conversion to Dementia Rates and Detection of Major Risk Factors Involved
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Espinosa, Ana, primary, Alegret, Montserrat, additional, Valero, Sergi, additional, Vinyes-Junqué, Georgina, additional, Hernández, Isabel, additional, Mauleón, Ana, additional, Rosende-Roca, Maitée, additional, Ruiz, Agustín, additional, López, Oscar, additional, Tárraga, Lluís, additional, and Boada, Mercè, additional
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- 2013
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17. Beneficial Effects of an Integrated Psychostimulation Program in Patients with Alzheimer's Disease.
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Ibarria, Marta, Alegret, Montserrat, Valero, Sergi, Morera, Amèrica, Guitart, Marina, Cañabate, Pilar, Moreno, Mariola, Lara, Susana, Diego, Susana, Hernández, Joan, Tantinyá, Natàlia, Vera, Maribel, Hernández, Isabel, Becker, James T., Ruíz, Agustín, Boada, Mercè, and Tárraga, Lluís
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ALZHEIMER'S disease ,AGE factors in cognition ,DEMENTIA patients ,HYDROPEROXIDES ,BLOOD circulation ,ALZHEIMER'S disease diagnosis ,ALZHEIMER'S disease treatment ,CHOLINESTERASE inhibitors ,ACTIVITIES of daily living ,COGNITION ,COMBINED modality therapy ,COMPARATIVE studies ,NEUROPSYCHOLOGICAL tests ,RESEARCH methodology ,MEDICAL cooperation ,PSYCHOTHERAPY ,QUESTIONNAIRES ,RESEARCH ,RESEARCH funding ,EVALUATION research ,TREATMENT effectiveness ,SEVERITY of illness index ,DISEASE progression ,PSYCHOLOGY ,THERAPEUTICS - Abstract
Background: The existing pharmacological treatments for Alzheimer's disease (AD) can only slow the progression of symptoms or delay admission to long-term care facilities. The beneficial effects of non-drug treatments are poorly studied.Objective: To describe the effects of an Integrated Psychostimulation Program (IPP) in patients with mild-moderate AD treated with acetylcholinesterase inhibitors; and to identify factors related to greater benefit of the IPP.Methods: 206 patients (mean age = 75.9 years; MMSE = 19.6) were evaluated before starting the IPP and 3, 6, 9, and 12 months later. Measures included: Mini-Mental State Examination (MMSE), Cognitive Subscale of Alzheimer's Disease Assessment Scale (ADAS-Cog), Rapid Disability Rating Scale (RDRS-2), and Neuropsychiatric Inventory Questionnaire (NPI-Q).Results: Patients remained cognitively stable (MMSE/ADAS-Cog) for more than 6 months and significantly worsened at 9-month and 12-month follow-ups, without clinically significant functional changes (RDRS-2) or psychiatric symptoms(NPI-Q). The mean annual change on MMSE and ADAS-Cog were 2.06 and 3.56 points, respectively, lower than the annual decline demonstrated previously in similar patients (2.4 and 4.5, respectively). 42.7% of patients maintained or improved global cognitive scores between baseline and 12-month follow-up. The patients who maintained cognitive functions were older than those who did not (77.5 versus 74.7 years).Conclusions: The IPP may be an effective treatment to maintain cognition, functionality, and psychiatric symptoms in AD patients pharmacologically treated, and older age seems to increase beneficial effects of IPP. [ABSTRACT FROM AUTHOR]- Published
- 2016
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18. A Two-Year Follow-Up of Cognitive Deficits and Brain Perfusion in Mild Cognitive Impairment and Mild Alzheimer's Disease
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Alegret, Montserrat, primary, Cuberas-Borrós, Gemma, additional, Vinyes-Junqué, Georgina, additional, Espinosa, Ana, additional, Valero, Sergi, additional, Hernández, Isabel, additional, Roca, Isabel, additional, Ruíz, Agustín, additional, Rosende-Roca, Maitée, additional, Mauleón, Ana, additional, Becker, James T., additional, Castell-Conesa, Joan, additional, Tárraga, Lluís, additional, and Boada, Mercè, additional
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- 2012
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19. The MTHFD1L Gene rs11754661 Marker is Not Associated with Alzheimer's Disease in a Sample of the Spanish Population
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Ramírez-Lorca, Reposo, primary, Boada, Mercé, additional, Antúnez, Carmen, additional, López-Arrieta, Jesús, additional, Moreno-Rey, Concha, additional, Hernández, Isabel, additional, Marín, Juan, additional, Gayán, Javier, additional, González-Pérez, Antonio, additional, Alegret, Montserrat, additional, Tárraga, Lluis, additional, Real, Luis M., additional, and Ruiz, Agustín, additional
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- 2011
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20. Brain Perfusion Correlates of Visuoperceptual Deficits in Mild Cognitive Impairment and Mild Alzheimer's Disease
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Alegret, Montserrat, primary, Vinyes-Junqué, Georgina, additional, Boada, Mercè, additional, Martínez-Lage, Pablo, additional, Cuberas, Gemma, additional, Espinosa, Ana, additional, Roca, Isabel, additional, Hernández, Isabel, additional, Valero, Sergi, additional, Rosende-Roca, Maitée, additional, Mauleón, Ana, additional, Becker and, James T., additional, and Tárraga, Lluís, additional
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- 2010
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21. CALHM1 P86L Polymorphism is Associated with Late-Onset Alzheimer's Disease in a Recessive Model
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Boada, Mercè, primary, Antúnez, Carmen, additional, López-Arrieta, Jesús, additional, Galán, José Jorge, additional, Morón, Francisco J., additional, Hernández, Isabel, additional, Marín, Juan, additional, Martínez-Lage, Pablo, additional, Alegret, Montserrat, additional, Carrasco, Jose M., additional, Moreno, Concha, additional, Real, Luis M., additional, González-Pérez, Antonio, additional, Tárraga, Lluís, additional, and Ruiz, Agustín, additional
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- 2010
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22. GOLPH2 Gene Markers are Not Associated with Alzheimer's Disease in a Sample of the Spanish Population
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Antúnez, Carmen, primary, Boada, Mercé, additional, López-Arrieta, Jesús, additional, Ramirez-Lorca, Reposo, additional, Hernández, Isabel, additional, Marín, Juan, additional, Martínez-Lage, Pablo, additional, González-Pérez, Antonio, additional, Jorge Galan, José, additional, Gayán, Javier, additional, Real, Luis M., additional, and Ruiz, Agustín, additional
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- 2009
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23. Association of TMEM106B rs1990622 Marker and Frontotemporal Dementia: Evidence for a Recessive Effect and Meta-Analysis.
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Hernández, Isabel, Rosende-Roca, Maitée, Alegret, Montserrat, Mauleón, Ana, Espinosa, Ana, Vargas, Liliana, Sotolongo-Grau, Oscar, Tárraga, Lluís, Boada, Mercè, and Ruiz, Agustín
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- *
FRONTOTEMPORAL dementia , *DEMENTIA , *MOLECULAR epidemiology , *MEMBRANE proteins , *BIOMARKERS , *GENETICS - Abstract
Transmembrane Protein 106B SNP rs1990622 was recently shown to modify the risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTD-TDP). An independent replication study of this genetic variant was performed in 381 individuals from Catalonia (Spain). By applying a recessive model, a tendency toward an association with FTD risk was observed in our case-control study (age- and gender-adjusted odds ratio = 0.57; p = 0.082). Importantly, meta-analysis of available studies also supports a recessive effect for rs1990622 CC genotype (OR = 0.70; CI 95% [0.57-0.85]; p = 0.0003) and demonstrates the existence of statistical heterogeneity due to an inherent pathological heterogeneity between series (p = 0.00014). We conclude that TMEM106B is associated with FTD, although the extent of this effect is difficult to be estimated by using clinical FTD series. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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24. Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy
- Author
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Ferrer, Isidro, primary, Hernández, Isabel, additional, Puig, Berta, additional, Jesús Rey, María, additional, Ezquerra, Mario, additional, Tolosa, Eduardo, additional, and Boada, Merce, additional
- Published
- 2004
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25. Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy.
- Author
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Ferrer, Isidro, Hernández, Isabel, Puig, Berta, Rey, María Jesús, Ezquerra, Mario, Tolosa, Eduardo, and Boada, Merce
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- *
UBIQUITIN , *DENTATE gyrus , *DEMENTIA , *ALZHEIMER'S disease , *IMMUNOGLOBULINS - Abstract
Neuropathological and biochemical findings are reported in a patient who had suffered from frontotemporal dementia associated with a P310L mutation in the tau gene and included in the H1 haplotype. tau accumulation, as revealed with phospho-specific anti-tau antibodies Thr181, Ser199, Ser202, Ser214, Ser262, Ser396, Ser422 and AT8 (Ser202 and Thr205), was found in neurons with pre-tangles, and astrocytes and oligodendrocytes through the brain. The most characteristic feature was tau immunoreactivity decorating the perinuclear region and small cytoplasmic aggregates designed as mini-Pick-like bodies, mainly in the dentate gyrus. Inclusions were not stained with anti-ubiquitin antibodies and did not recruit tubulins. Tau accumulation in individual cells was associated with increased expression of kinases linked with tau phosphorylation, mainly active (phosphorylated) stress kinases SAPK/JNK and p38 (SAPK/JNK-P and p38-P). Phosphorylated GSK-3β at Ser9 (GSK-3β-P), that inactivates the kinase, was particularly abundant in mini-Pick-like bodies, thus suggesting alternative roles of GSK-3 probably involved in cell survival. Western blots of sarkosyl-insoluble fractions revealed a double band pattern of phospho-tau of 68/66 kDa and 64 kDa in the hippocampus and white matter in the P310L mutation. Sarkosyl-insoluble fractions of the hippocampus were enriched in p38-P and GSK-3β-P in Alzheimer's disease (AD) cases, processed in parallel for comparative purposes, but not in the P310L mutation. In addition, no bands of high molecular weight were found in P310L in contrast with AD in these fractions. These findings indicate that the major sites of tau phosphorylation, and the expression of kinases involved in tau phosphorylation are active in P310L mutation as in AD and other tauopathies. Yet the P310L mutation has particular phospho-tau inclusions that are not tag with ubiquitin and appear to be rather soluble when compared with AD. [ABSTRACT FROM AUTHOR]
- Published
- 2003
26. An Insertion Within SIRPβ1 Shows a Dual Effect Over Alzheimer's Disease Cognitive Decline Altering the Microglial Response.
- Author
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García-Alberca JM, de Rojas I, Sanchez-Mejias E, Garrido-Martín D, Gonzalez-Palma L, Jimenez S, Pino-Angeles A, Cruz-Gamero JM, Mendoza S, Alarcón-Martín E, Muñoz-Castro C, Real LM, Tena JJ, Polvillo R, Govantes F, Lopez A, Royo-Aguado JL, Navarro V, Gonzalez I, Ruiz M, Reyes-Engel A, Gris E, Bravo MJ, Lopez-Gutierrez L, Mejias-Ortega M, De la Guía P, López de la Rica M, Ocejo O, Torrecilla J, Zafra C, Nieto MD, Urbano C, Jiménez-Sánchez R, Pareja N, Luque M, García-Peralta M, Carrillejo R, Furniet MDC, Rueda L, Sánchez-Fernández A, Mancilla T, Peña I, García-Casares N, Moreno-Grau S, Hernández I, Montrreal L, Quintela I, González-Pérez A, Calero M, Franco-Macías E, Macías J, Menéndez-González M, Frank-García A, Huerto Vilas R, Diez-Fairen M, Lage C, García-Madrona S, García-González P, Valero S, Sotolongo-Grau O, Pérez-Cordón A, Rábano A, Arias Pastor A, Pastor AB, Espinosa A, Corma-Gómez A, Martín Montes Á, Sanabria Á, Martínez Rodríguez C, Buiza-Rueda D, Rodriguez-Rodriguez E, Ortega G, Alvarez I, Rosas Allende I, Pineda JA, Rosende-Roca M, Bernal Sánchez-Arjona M, Fernández-Fuertes M, Alegret M, Roberto N, Del Ser T, Garcia-Ribas G, Sánchez-Juan P, Pastor P, Piñol-Ripoll G, Bullido MJ, Álvarez V, Mir P, Medina M, Marquié M, Sáez ME, Carracedo Á, Laplana M, Tomas-Gallardo L, Orellana A, Tárraga L, Boada M, Fibla Palazon J, Vitorica J, Ruiz A, Guigo R, Gutierrez A, and Royo JL
- Subjects
- Humans, Amyloid beta-Peptides metabolism, Microglia metabolism, Phagocytosis, Alzheimer Disease diagnostic imaging, Alzheimer Disease genetics, Cognitive Dysfunction diagnostic imaging, Cognitive Dysfunction genetics, Cognitive Dysfunction metabolism, Receptors, Cell Surface metabolism
- Abstract
Background: Microglial dysfunction plays a causative role in Alzheimer's disease (AD) pathogenesis. Here we focus on a germline insertion/deletion variant mapping SIRPβ1, a surface receptor that triggers amyloid-β(Aβ) phagocytosis via TYROBP., Objective: To analyze the impact of this copy-number variant in SIRPβ1 expression and how it affects AD molecular etiology., Methods: Copy-number variant proxy rs2209313 was evaluated in GERALD and GR@ACE longitudinal series. Hippocampal specimens of genotyped AD patients were also examined. SIRPβ1 isoform-specific phagocytosis assays were performed in HEK393T cells., Results: The insertion alters the SIRPβ1 protein isoform landscape compromising its ability to bind oligomeric Aβ and its affinity for TYROBP. SIRPβ1 Dup/Dup patients with mild cognitive impairment show an increased cerebrospinal fluid t-Tau/Aβ ratio (p = 0.018) and a higher risk to develop AD (OR = 1.678, p = 0.018). MRIs showed that Dup/Dup patients exhibited a worse initial response to AD. At the moment of diagnosis, all patients showed equivalent Mini-Mental State Examination scores. However, AD patients with the duplication had less hippocampal degeneration (p < 0.001) and fewer white matter hyperintensities. In contrast, longitudinal studies indicate that patients bearing the duplication allele show a slower cognitive decline (p = 0.013). Transcriptional analysis also shows that the SIRPβ1 duplication allele correlates with higher TREM2 expression and an increased microglial activation., Conclusions: The SIRPβ1 internal duplication has opposite effects over MCI-to-Dementia conversion risk and AD progression, affecting microglial response to Aβ. Given the pharmacological approaches focused on the TREM2-TYROBP axis, we believe that SIRPβ1 structural variant might be considered as a potential modulator of this causative pathway.
- Published
- 2024
- Full Text
- View/download PDF
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