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Eml® cream is frequently used in surgical dermatology and in anesthesiology, for instance, during vascular surgery procedures. Because local anesthetics can have a vasoactive effect in addition to producing analgesia, we decided to document the effect of 5% Eml® cream on cutaneous circulation in a prospective, placebo-controlled study. Skin circulation was monitored continuously under standardized conditions using video capillaroscopy, laser Doppler flowmetry and skin temperature. Recordings were made at the nailfold of the fourth finger (DIV) of the left hand of 12 volunteers with healthy veins over an observation period of 60 minutes under either Eml® occlusive dressing or an occlusive dressing with placebo. Mean capillary red blood cell velocity changed only minimally under the Eml® occlusive dressing, while placebo occlusive dressing led to a reduction of mean capillary red blood cell velocity from 0.21 mm/s to 0.12 mm/s (p < 0.01). There was no statistically significant change of arterial capillary diameter under Eml® or placebo occlusive dressing. Skin temperature dropped after 60 minutes of Eml® cream occlusive dressing from an initial 26.7 to 24.0°C (-10.1%; p < 0.02). The same duration of placebo caused skin temperature to drop from 27.6 to 23.0°C (-16.7%; p < 0.001). Laser Doppler flux (543 nm) rose 13% with Eml® (p = 0.9) and dropped 41.9% under placebo occlusive dressing (p < 0.03). Eml® cream upregulated nutritive perfusion. No clinically relevant vasoconstrictive effects are expected from an application period of 60 minutes. [ABSTRACT FROM AUTHOR]