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9 results on '"Confaloni, A."'

1. Circulating miR-127-3p as a Potential Biomarker for Differential Diagnosis in Frontotemporal Dementia

Author

Piscopo, Paola, primary, Grasso, Margherita, additional, Puopolo, Maria, additional, D’Acunto, Emanuela, additional, Talarico, Giuseppina, additional, Crestini, Alessio, additional, Gasparini, Marina, additional, Campopiano, Rosa, additional, Gambardella, Stefano, additional, Castellano, Anna Elisa, additional, Bruno, Giuseppe, additional, Denti, Michela A., additional, and Confaloni, Annamaria, additional

Published
2018
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2. A Novel Mutation in the Predicted TMIII Domain of the PSEN2 Gene in an Italian Pedigree with Atypical Alzheimer's Disease

Author

Piscopo, P, Talarico, Giuseppina, Crestini, A, Gasparini, Marina, MALVEZZI CAMPEGGI, L, Piacentini, E, Lenzi, Gian Luigi, Bruno, Giuseppe, Confaloni, A, ALZHEIMERS DIS, J., and Apr

Subjects
Male, DNA Mutational Analysis, Disease, Neuropsychological Tests, Biology, Presenilin, Alzheimer Disease, Presenilin-2, mental disorders, PSEN2, Serine, PSEN1, Humans, Memory impairment, Cysteine, Cognitive decline, Gene, Aged, Genetics, General Neuroscience, General Medicine, Middle Aged, Pedigree, Protein Structure, Tertiary, nervous system diseases, Psychiatry and Mental health, Clinical Psychology, Transmembrane domain, Italy, Mutation, Female, Geriatrics and Gerontology, Cognition Disorders
Abstract

Alzheimer's disease (AD) is characterized by accumulation of toxic amyloid-beta (Abeta) in the brain, with neuronal death, and an associated increased Abeta(42/40) ratio. Several mutations in presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid-beta precursor protein are involved in the etiology of familial AD (FAD); these mutations alter the Abeta(42/40) ratio and promote apoptosis. We describe an Italian pedigree linked to a novel mutation (S175C) at the third transmembrane domain of PSEN2. Clinical phenotype in these individuals is characterized by fast cognitive decline with progressive memory impairment, early involvement of executive functions, behavioral disturbances, and extrapyramidal signs.

Published
2010
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3. Gender Effects on Plasma PGRN Levels in Patients with Alzheimer's Disease: A Preliminary Study

Author

Giuseppina Talarico, Alessio Crestini, Nicola Vanacore, Annamaria Confaloni, Elio Scarpini, Roberto Rivabene, Paola Piscopo, Daniela Galimberti, and Giuseppe Bruno

Subjects
Oncology, Male, medicine.medical_specialty, Pathology, Aging, alzheimer's disease, gender, plasma, progranulin, Enzyme-Linked Immunosorbent Assay, Pilot Projects, Disease, Neuropsychological Tests, Positive correlation, Cohort Studies, Progranulins, Alzheimer Disease, Internal medicine, mental disorders, medicine, Humans, In patient, Aged, Psychiatric Status Rating Scales, Sex Characteristics, General Neuroscience, General Medicine, Frontotemporal lobar degeneration, DNA, medicine.disease, Psychiatry and Mental health, Clinical Psychology, Psychiatric status rating scales, Mutation, Biomarker (medicine), Intercellular Signaling Peptides and Proteins, Female, Geriatrics and Gerontology, Psychology, Biomarkers, Sex characteristics, Cohort study
Abstract

Plasma progranulin (PGRN) levels constitute a potentially invaluable biomarker for neurodegenerative diseases including frontotemporal lobar degeneration (FTLD) and, perhaps, Alzheimer's disease (AD). We assessed plasma PGRN levels in 107 AD patients, 36 FTLD patients, and 107 controls. We found that, in female AD patients, there is a positive correlation between PGRN levels and age. Although no significant differences were found between patients and controls, we observed higher levels in females compared to males; in AD patients, a positive correlation between PGRN levels and age was observed in females. In conclusion, our data suggest that PGRN may not be a good biomarker for AD; moreover, gender may influence the plasma PGRN levels of AD patients.

Published
2013

4. PRNP P39L Variant is a Rare Cause of Frontotemporal Dementia in Italian Population

Author

Oldoni, Emanuela, primary, Fumagalli, Giorgio G., additional, Serpente, Maria, additional, Fenoglio, Chiara, additional, Scarioni, Marta, additional, Arighi, Andrea, additional, Bruno, Giuseppe, additional, Talarico, Giuseppina, additional, Confaloni, Annamaria, additional, Piscopo, Paola, additional, Nacmias, Benedetta, additional, Sorbi, Sandro, additional, Rainero, Innocenzo, additional, Rubino, Elisa, additional, Pinessi, Lorenzo, additional, Binetti, Giuliano, additional, Ghidoni, Roberta, additional, Benussi, Luisa, additional, Grande, Giulia, additional, Arosio, Beatrice, additional, Bursey, Devan, additional, Kauwe, John S., additional, Cioffi, Sara MG, additional, Arcaro, Marina, additional, Mari, Daniela, additional, Mariani, Claudio, additional, Scarpini, Elio, additional, and Galimberti, Daniela, additional

Published
2016
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5. SORL1 Gene is Associated with the Conversion from Mild Cognitive Impairment to Alzheimer’s Disease

Author

Piscopo, Paola, primary, Tosto, Giuseppe, additional, Belli, Chiara, additional, Talarico, Giuseppina, additional, Galimberti, Daniela, additional, Gasparini, Marina, additional, Canevelli, Marco, additional, Poleggi, Anna, additional, Crestini, Alessio, additional, Albani, Diego, additional, Forloni, Gianluigi, additional, Lucca, Ugo, additional, Quadri, Pierluigi, additional, Tettamanti, Mauro, additional, Fenoglio, Chiara, additional, Scarpini, Elio, additional, Bruno, Giuseppe, additional, Vanacore, Nicola, additional, and Confaloni, Annamaria, additional

Published
2015
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7. Replication Study to Confirm the Role of CYP2D6 Polymorphism rs1080985 on Donepezil Efficacy in Alzheimer's Disease Patients

Author

Albani, Diego, primary, Boneschi, Filippo Martinelli, additional, Biella, Gloria, additional, Giacalone, Giacomo, additional, Lupoli, Sara, additional, Clerici, Francesca, additional, Benussi, Luisa, additional, Ghidoni, Roberta, additional, Galimberti, Daniela, additional, Squitti, Rosanna, additional, Mariani, Stefania, additional, Confaloni, Annamaria, additional, Bruno, Giuseppe, additional, Mariani, Claudio, additional, Scarpini, Elio, additional, Binetti, Giuliano, additional, Magnani, Giuseppe, additional, Franceschi, Massimo, additional, and Forloni, Gianluigi, additional

Published
2012
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9. gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells.

Author

Fuso, Andrea, Cavallaro, Rosaria A, Zampelli, Alessandro, D'Anselmi, Fabrizio, Piscopo, Paola, Confaloni, Annamaria, and Scarpa, Sigfrido

Subjects
ADENOSYLMETHIONINE, ALZHEIMER'S disease, ANTIOXIDANTS, VITAMIN deficiency, BIOCHEMISTRY, CELL lines, COMPARATIVE studies, DNA probes, FOLIC acid, GLIOMAS, PHENOMENOLOGY, RESEARCH methodology, MEDICAL cooperation, MEMBRANE proteins, NEUROBLASTOMA, POLYMERASE chain reaction, PROTEIN precursors, PROTEOLYTIC enzymes, RESEARCH, VITAMIN B6 deficiency, WESTERN immunoblotting, HOMOCYSTEINE, OXIDATIVE stress, EVALUATION research, DNA methylation
Abstract

Multiple aspects of homocysteine metabolism were studied to understand the mechanism responsible for hyperhomocysteinemia toxicity in Alzheimer disease. Besides oxidative stress and vascular damage, homocysteine has also a great importance in regulating DNA methylation through S-adenosylmethionine, the main methyl donor in eukaryotes. Alterations of S-adenosylmethionine and methylation were evidenced in Alzheimer disease and in elderly. In order to clarify whether DNA methylation can provide the basis for amyloid-beta overproduction, we used human SK-N-BE neuroblastoma and A172 glioblastoma cell lines. We tested the effects of folate, B12 and B6 deprivation and S-adenosylmethionine addition on methylation metabolism. Our results indicate that homocysteine accumulation induced through vitamin B deprivation could impair the "Methylation Potential" with consequent presenilin 1, BACE and amyloid-beta upregulation. Moreover, we found that homocysteine alterations had an effect on neuroblastoma but not on glioblastoma cells; this suggests a possible differential role of the two cell types in Alzheimer disease. [ABSTRACT FROM AUTHOR]

Published
2007
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