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Mortality in CKD patients undergoing hemodialysis considerably high. Previous study showed that mortality in patients undergoing hemodialysis was strongly correlated with chronic inflammation. The current study examined whether the serum c-reative protein concentration (hsCRP) changed from pre- to post-dialysis. In addition, the current study also investigated the correlation between dialysis age and hsCRP in chronic kidney disease patients undergoing hemodialysis. The study was a case-series study of 30 patients with hemodialysis. The patients were devided into three group based on dialysis age. Hemodialysis had been undergone for 4 hours, using hemoflow F8HPS, polysulfone synthetic dialysis membrane, and bicarbonate dialysis fluid. The primary outcome was serum concentration of high-sensitivity C-reactive protein (hsCRP), which was assessed in the pre-and-post dialysis, measured using chemiluminescent method. Dialysis does increased the hsCRP post-dialysis. It resulted in significant (p

Intradialytic hypertension and hypotension are both independently associated with increased morbidity and mortality among patients with chronic hemodialysis. Prior studies investigate the role of endothelial dysfunction in the mechanism of adverse intradialytic blood pressure changes. The aim of the current study was to investigate the association of plasma asymmetric dimethylarginine (ADMA), a marker for endothelial dysfunction, concentration changes pre-to-post-dialysis with both intradialytic hypertension and intradialytic hypotension. The study was a case-control study of 36 patients with chronic hemodialysis (12 patients in each group for intradialytic hypertension, intradialytic hypotension, and stable blood pressure). Intradialytic blood pressure changes were defined as increased or decreased systolic blood pressure pre-to-post-dialysis ≥10 mmHg in ≥4/6 consecutive HD sessions. Dialysis resulted in significant reduction of the plasma ADMA concentration pre-to-post dialysis in each group (0.26±0.15µmol/L, p=0.00 in patients with intradialytic hypertension; 0.18±0.15µmol/L, p=0.01 in patients with intradialytic hypotension; 0.17±0.09µmol/L, p=0.00 in patients with stable blood pressure). The reduction of plasma ADMA concentration in patients with intradialytic hypertension was significantly different compared to control group (p=0.02), albeit the insignificant difference in patients with intradialytic hypotension (p=0.78). Plasma ADMA concentration changes pre-to-post dialysis was considered as an insignificant risk factor (OR=1.96, 95%CI [0.38-9.93, p=0.41]) for intradialytic hypertension.