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4. Raman Spectroscopy vs Voltammetry: A Voltammetric Approach to Elucidate Different Chemicals in a Range of Pharmaceutical Tablets.

Author

Alecrim, M. F., Macêdo, I. Y. L., Rodrigues, E. B., Moreno, E. K. G., Ghedini, P. C., Fernandez, C., Dos Santos, W. T. P., and Gil, E. S.

Subjects
RAMAN spectroscopy, ANALYTICAL chemistry, ACRYLONITRILE, REGRESSION analysis, ELECTROCHEMICAL analysis, VOLTAMMETRY
Abstract

Over the years, Electroanalysis has been widely applied to elucidate redox behavior of novel molecules. The selectivity and low cost are spotlight features in pharmacopeial methods of identification, that can be reached by voltammetric approaches. In this work, differential pulse voltammetric (DPV) profile and the slope of the linear regression obtained from calibration graphs along with the scan study are proposed as new perspective of identification assays. With the proposed methodology we were able to identify the similarities among DPV profile and the slopes obtained for each tablet. In addition, this new technology was successfully employed to identify the following chemicals: Paracetamol (PAR), Promethazine (PMZ), Diclofenac (DIC), Piroxicam (PRX), Indomethacin (IND) and Cyclobenzaprine (CBP) in pharmaceutical assays using Pencil Graphite Electrodes. Furthermore, our new methodology was effectively compared to Raman Spectroscopy for the analysis of the range of chemicals in the pharmaceutical assays. [ABSTRACT FROM AUTHOR]

Published
2019
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