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MEMS electret energy harvesting devices are believed promising to replace coin batteries in low-power consumption electronics such as wireless sensor nodes and wearable devices. However, the parasitic capacitance of the interdigital electrodes imposes significant restrictions to enhancing the power output. To address this issue, this paper presents a novel low-k electrode structure based on a new model of the parasitic capacitance in electret energy harvesters. By employing the trench-filled parylene technology, metal electrodes suspended with deep honeycomb parylene structures have been prototyped. Thanks to the high air volume fraction (76%) of the honeycomb parylene structure, the effective relative permittivity κeff surrounding the electrodes is reduced to as low as 1.8 when the air gap is 90 µm between the electret surface and the counter electrode. As a result, the parasitic capacitance in the electret energy harvester is decreased by 36% compared with that of electrodes on glass substrates, which leads to a 35% increase in the power output. [ABSTRACT FROM AUTHOR]

We present the first endoscopic imaging probe that combines full-field white light video microscopy and 3D optical coherence tomography (OCT) in a single miniaturized instrument. Designed as an instrument for the working channels of conventional endoscopes, the presented system has dimensions of mm3 (l  ×  w  ×  h) and is an important step towards practical multi-modal optical biopsy systems for clinical use. The video modality has a sensor-limited resolution and a total field of view of 10 μm and 1.17 mm in diameter, respectively. The OCT modality works in a scanned imaging arrangement and provides 3D optical tomograms with a lateral resolution of 43.5 μm. An integrated tubular piezoelectric fiber scanner is used to perform en face scanning necessary for the 3D OCT measurements. The entire system is assembled and encapsulated within a glass package fabricated via 3D laser microstructuring, a technology which addresses the major issues of micro-optic assembly precision and biocompatibility. [ABSTRACT FROM AUTHOR]

Remote control over fusion of single cells and vesicles has a great potential in biological and chemical research allowing both transfer of genetic material between cells and transfer of molecular content between vesicles. Membrane fusion is a critical process in biology that facilitates molecular transport and mixing of cellular cytoplasms with potential formation of hybrid cells. Cells precisely regulate internal membrane fusions with the aid of specialized fusion complexes that physically provide the energy necessary for mediating fusion. Physical factors like membrane curvature, tension and temperature, affect biological membrane fusion by lowering the associated energy barrier. This has inspired the development of physical approaches to harness the fusion process at a single cell level by using remotely controlled electromagnetic fields to trigger membrane fusion. Here, we critically review various approaches, based on lasers or electric pulses, to control fusion between individual cells or between individual lipid vesicles and discuss their potential and limitations for present and future applications within biochemistry, biology and soft matter. [ABSTRACT FROM AUTHOR]

A forward-looking endoscopic optical coherence tomography (OCT) probe featuring a Fourier-plane fiber scanner is designed, manufactured and characterized. In contrast to common image-plane fiber scanners, the Fourier-plane scanner is a telecentric arrangement that eliminates vignetting and spatial resolution variations across the image plane. To scan the OCT beam in a spiral pattern, a tubular piezoelectric actuator is used to resonate an optical fiber bearing a collimating GRIN lens at its tip. The free-end of the GRIN lens sits at the back focal plane of an objective lens, such that its rotation replicates the beam angles in the collimated region of a classical telecentric 4f optical system. Such an optical arrangement inherently has a low numerical aperture combined with a relatively large field-of-view, rendering it particularly useful for endoscopic OCT imaging. Furthermore, the optical train of the Fourier-plane scanner is shorter than that of a comparable image-plane scanner by one focal length of the objective lens, significantly shortening the final arrangement. As a result, enclosed within a 3D printed housing of 2.5 mm outer diameter and 15 mm total length, the developed probe is the most compact forward-looking endoscopic OCT imager to date. Due to its compact form factor and compatibility with real-time OCT imaging, the developed probe is also ideal for use in the working channel of flexible endoscopes as a potential optical biopsy tool. [ABSTRACT FROM AUTHOR]