The bookstore is an integral part of campus public service, and it is an essential place for reading, learning and spending for teachers and students. Provided the current management and development problems faced by old campus bookstores, this article takes the old campus bookstore in the Huangjiahu campus of Wuhan University of Science and Technology as a research case while uses space syntax theory, Depthmap software, and axis models to analyzes and evaluate accessibility, and then optimize campus old location and layout of bookstores. Simultaneously, by using the analytic hierarchy process, the simulated bookstore sites of selection in the campus are tested at the target level, decision level and plan level. This article aims to propose optimization methods for the management and development of old campus bookstores from the perspective of spatial location selection through qualitative quantification and provide constructive references for similar research.