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Your search keyword '"Richard J. Bridges"' showing total 2 results
Start Over Author "Richard J. Bridges" Publisher international union of crystallography
2 results on '"Richard J. Bridges"'

1. Ethyl 4-{1-[(2,4-dinitrophenyl)hydrazono]ethyl}-5-(2-naphthylmethoxymethyl)isoxazole-3-carboxylate

Author

Nicholas R. Natale, Brendan Twamley, Monica I. Szabon-Watola, Richard J. Bridges, Sarjubhai Patel, and Trideep Rajale

Subjects
Crystallography, QD901-999
Abstract

The title compound, C26H23N5O8, was prepared and its structure investigated to further develop a working hypothesis for the essential binding pharmacophore for ligands of the System Xc- transporter [Patel et al. (2004). Neuropharmacology, 46, 273–284]. The hydrazone group displays an E geometry and the isoxazole double bond and C=N group of the hydrazone are in an s-cis relationship. The secondary amino NH group forms an intramolecular N—H...O hydrogen bond to a ring nitro group. There is a dihedral angle of 44.27 (5)° between the isoxazole plane and the hydrazone group plane.

Published
2009
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2. Ethyl 4-{1-[(2,4-dinitrophenyl)hydrazono]ethyl}-5-(2-naphthylmethoxymethyl)isoxazole-3-carboxylate

Author

Brendan Twamley, Monica I. Szabon-Watola, Richard J. Bridges, Sarjubhai A. Patel, Nicholas R. Natale, and Trideep Rajale

Subjects
chemistry.chemical_classification, Crystallography, Double bond, 010405 organic chemistry, Hydrogen bond, Hydrazone, General Chemistry, Dihedral angle, 010402 general chemistry, Condensed Matter Physics, Ring (chemistry), Organic Papers, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, 3. Good health, chemistry.chemical_compound, chemistry, QD901-999, Nitro, General Materials Science, Pharmacophore, Isoxazole
Abstract

The title compound, C26H23N5O8, was prepared and its structure investigated to further develop a working hypothesis for the essential binding pharmacophore for ligands of the System Xc- transporter [Patel et al. (2004). Neuropharmacology, 46, 273–284]. The hydrazone group displays an E geometry and the isoxazole double bond and C=N group of the hydrazone are in an s-cis relationship. The secondary amino NH group forms an intramolecular N—H...O hydrogen bond to a ring nitro group. There is a dihedral angle of 44.27 (5)° between the isoxazole plane and the hydrazone group plane.

Published
2009

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