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Your search keyword '"A. S. Brichagina"' showing total 2 results
Start Over Author "A. S. Brichagina" Publisher international medical research and development corporation
2 results on '"A. S. Brichagina"'

1. Oxidative Stress Intensity in Children and Adolescents with a New Coronavirus Infection

Author

Lyubov V. Rychkova, Marina A. Darenskaya, Natalya V. Semenova, Sergey I. Kolesnikov, Alla G. Petrova, Olga A. Nikitina, Anastasia S. Brichagina, and Lyubov I. Kolesnikova

Subjects
covid-19, oxidative stress index, children, adolescents, polymerase chain reaction, Medicine
Abstract

The aim of our research was to assess the intensity of oxidative stress (OS) in children and adolescents with COVID-19 using the oxidative stress index (OSI). Methods and Results: The study was conducted between May 2020 and March 2021. The main group included 17 children and adolescents [8(47.1%) boys and 9(52.9%) girls; mean age of 12.35±4.01 years] with diagnosed COVID-19 infection (mild to moderate course) selected as a result of the primary diagnostic examination from among those admitted to hospitalization at the Irkutsk Regional Infectious Diseases Clinical Hospital. The control group included 17 healthy children and adolescents (average age of 12.35±4.01 years) matched by copy-pair type. The obtained data indicated statistically significant differences in a number of parameters between children and adolescents with COVID-19 and the control groups. We found statistically significant higher levels of LPO products (CDs, P

Published
2022
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2. Advanced Oxidation Protein Products and the CLOCK 3111T/C Single Nucleotide Polymorphism in Menopausal Women with Insomnia

Author

Natalya V. Semenova, Irina M. Madaeva, Anastasiya S. Brichagina, Olga A. Nikitina, Sergey I. Kolesnikov, and Lyubov I. Kolesnikova

Subjects
clock 3111t/c snp, insomnia, lcsh:R, menopause, lcsh:Medicine, protein oxidation
Abstract

Background: The aim of this study was to assess the dependence of advanced oxidation protein products (AOPPs) levels on the genotype of the CLOCK 3111T/C SNP in Caucasian menopausal women with and without insomnia. Methods and Results: The study involved 105 Caucasian menopausal women volunteers aged between 45 and 60 years. The Pittsburgh Sleep Quality Index, PSQI, Insomnia Severity Index (ISI), and Epworth Sleepiness Scale (ESS) were employed. The study of the CLOCK 3111T/C SNP (rs1801260) was performed by PCR. The blood level of advanced oxidation protein products (AOPPs) was detected by IEMA. Based on the results of a clinical-anamnestic examination, the women were divided into two groups: the main (with insomnia) and the control (without insomnia). Given the small number of women carrying the CC genotype of the CLOCK 3111T/C SNP, the СС carriers and TC carriers were combined into one group as the carriers of the minor 3111C allele. There were no statistically significant differences in the AOPP levels between carriers of different genotypes (TT genotype and TC+CC genotypes) in controls and patients. A comparative analysis of AOPP levels in the women of the main and control groups showed higher AOPP levels in women with insomnia carrying the TT genotype than in the control of the same genotype (P=0.013). Conclusion: Insomnia in menopausal women is associated with increased protein oxidation only in carriers of the TT genotype of the CLOCK 3111T/C SNP.

Published
2020

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