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Magnetic Particle Imaging (MPI) is a fast imaging technique for the visualization of the distribution of superparamagnetic iron-oxide nanoparticles (SPIONs) in 3D. For spatial encoding, a field free area is moved rapidly through the field of view (FOV) generating a localized signal. Fast moving samples, e.g., a bolus of SPIONs traveling through the large veins in the human body carried by blood flow with velocities in the order of ~45 cm/s and higher, cause temporal blurring in MPI measurements using common sequences and reconstruction techniques. This hampers the evaluation of dynamics of rapidly moving samples. In this abstract, initial results of rapidly moving samples in form of SPION boluses visualized within an MPI scanner are shown., International Journal on Magnetic Particle Imaging IJMPI, Vol 9 No 1 Suppl 1 (2023)

Phantoms of blood vessels are an important part of flow measurements and should behave as realistic as possible compared to human blood vessels. A step-by-step guide is presented on how to obtain realistic 3D models of blood vessels applicable for 3D printing and simulation studies. The resulting 3D models have realistic dimensions, are waterproof and could be used in a human-sized MPI scanner. The 3D printed phantoms with vascular pathologies like aneurysm or stenosis were used in static and real-time bolus tracking measurements., International Journal on Magnetic Particle Imaging IJMPI, Vol 9 No 1 Suppl 1 (2023)

MPI has been on a trajectory towards clinical application in humans for years. As scanners and techniques mature, clinical testing is effectively prohibited by the lack of a clinically approved tracer. This changes now by the reintroduction of a Ferucarbotran-based tracer into the market, Resotran®. Although initially intended for use in MRI, we tested Resotran® for its viability in MPI. The other Ferucarbotran-based tracer fit for MRI and MPI is Resovist®, which is well known and characterized but was discontinued years ago. We present initial data on the characterization of Resotran® in comparison to Resovist®., International Journal on Magnetic Particle Imaging IJMPI, Vol 9 No 1 Suppl 1 (2023)

Based on a novel open design implementing the so-called traveling wave MPI approach, the open interventional MPI (iMPI) system provides imaging of tracers based on superparamagnetic iron oxide nanoparticles (SPIONs) with high sensitivity, optimal patient handling and would even allow hybrid imaging of magnetic tracers within gold standard x-ray based interventional angiography systems. In initial experiments, the feasibility of a human-sized interventional MPI scanner with real-time data reconstruction and image visualization is demonstrated within a percutaneous transluminal angioplasty (PTA)., International Journal on Magnetic Particle Imaging IJMPI, Vol 9 No 1 Suppl 1 (2023)

Endovascular treatment of human aneurysms with stent grafts is an established therapeutic strategy to treat ruptured and unruptured arterial aneurysms. These stents are covered with a membrane that blocks blood flow to the aneurysm and promotes healing of the vessel. To date, digital subtraction angiography (DSA) has been gold standard for image-guided stent graft application. However, DSA is associated with significant disadvantages including its invasiveness, the need for potentially nephrotoxic iodine-based contrast agents and exposure to ionizing radiation for patients and clinical staff. Magnetic particle imaging (MPI) is a fast and sensitive tomographic imaging technique that uses magnetic fields to visualize superparamagnetic iron-oxide nanoparticles (SPIONs). The advantages of MPI include the background- and radiation-free visualization of SPION-tracers. The aim of this proof-of-concept study was to demonstrate the potential of MPI for image-guided application of covered stents in a 3D printed realistic aneurysm phantom., International Journal on Magnetic Particle Imaging IJMPI, Vol 9 No 1 Suppl 1 (2023)

Investigation of influence of metallic endoprostheses on MPI functionality in a human-sized MPI scanner. No relevant impairment of imaging from the presence of endoprosthesis could be found., International Journal on Magnetic Particle Imaging IJMPI, Vol 9 No 1 Suppl 1 (2023)