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Background: The use of homoeopathic remedies to prevent infectious diseases, homoeoprophylaxis (HP), was first described over 100 years ago. To date, no systematic studies have been performed to identify the attitudes that current practitioners hold about HP or current trends in the use of HP. Aims: This study aimed to discover attitudes to HP amongst accredited homeopathic practitioners particularly with respect to overall acceptance, the context of use, and preferred remedies. Methodology: Two international surveys were conducted in 2014. Responses were received from 1,124 homeopaths in 35 countries; 104 of whom responded to both surveys. Results: A large proportion of respondents have positive attitudes to HP and currently use HP in their practice. However, responses also indicate that knowledge about HP is chequered. Confidence in the evidence base of HP also is variable. Conclusion: Results indicate that HP is widely practiced, however, further research is needed to improve confidence in the evidence base of HP, and better programs are needed to ensure that education about HP is enhanced. [ABSTRACT FROM AUTHOR]