1. How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients?
- Author
-
Ferini G, Tripoli A, Molino L, Cacciola A, Lillo S, Parisi S, Umina V, Illari SI, Marchese VA, Cravagno IR, Borzì GR, and Valenti V
- Subjects
- Administration, Topical, Aged, Aged, 80 and over, Beclomethasone administration & dosage, Enema methods, Humans, Hyaluronic Acid administration & dosage, Italy, Male, Middle Aged, Organ Sparing Treatments methods, Proctitis etiology, Prostatic Neoplasms pathology, Radiation Dose Hypofractionation, Radiation Injuries prevention & control, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy, Image-Guided adverse effects, Radiotherapy, Image-Guided methods, Retrospective Studies, Anti-Inflammatory Agents administration & dosage, Proctitis prevention & control, Prostatic Neoplasms drug therapy, Prostatic Neoplasms radiotherapy, Radiotherapy, Intensity-Modulated adverse effects, Radiotherapy, Intensity-Modulated methods
- Abstract
Background/aim: To evaluate if topical support therapy during static-intensity modulated radiotherapy (sIMRT) course is able to equal the characteristic minimum risk for radiation proctitis of Image-guided volumetric modulated arc therapy (IG-VMAT) treatment among localized prostate cancer patients., Patients and Methods: Rectal toxicity data of the above patients were retrospectively collected throughout three different clinical periods at our Radiotherapy Deparment: from October 2011 to December 2012, prostate cancer patients were treated with sIMRT and in advance supported by means of daily topical corticosteroids; from January 2013 to November 2016, topical corticosteroids were replaced by daily hyaluronic acid enemas; from December 2016 to May 2018 eligible patients were treated with newly introduced IG-VMAT supported by only on-demand topical corticosteroids., Results: Among 359 eligible patients, IG-VMAT was proven generally more effective than sIMRT supported by topical medications in terms of proctitis reduction, although without clinical and practical relevance., Conclusion: Topical medications might have a role in radiation proctitis prevention., (Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF