1. Changing Patterns of Distant Metastasis in Patients With Lower Rectal Cancer Undergoing Intraoperative Radiotherapy.
- Author
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Masaki T, Matsuoka H, Kishiki T, Kojima K, Tonari A, Aso N, Beniya A, Iioka A, Wakamatsu T, and Sunami E
- Subjects
- Combined Modality Therapy, Humans, Intraoperative Period, Neoplasm Recurrence, Local, Postoperative Complications, Rectum, Rectal Neoplasms radiotherapy, Rectal Neoplasms surgery
- Abstract
Background/aim: Local radiotherapy for primary tumors may increase the incidence of distant metastasis. However, the patterns of target organs have not been clarified yet., Patients and Methods: In our randomized controlled trial examining the oncological efficacy of intraoperative radiotherapy (IORT) for advanced lower rectal cancer, the details of the metastatic organs were evaluated., Results: In the IORT group (38 patients), 2 patients had metastasis in the liver and lung simultaneously, 9 in the liver, and 4 in the lung. In the control group (38 patients), 3 had metastasis in the lung, and 2 in the liver. The IORT group tended to have liver metastases more frequently (p=0.058). Among patients with liver metastases, distant metastasis-free intervals were significantly shorter in the IORT group, however, no significant difference was observed among patients with lung metastases., Conclusion: After curative rectal cancer surgery with IORT, liver metastasis may be increased and accelerated., (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2020
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