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Start Over Author "Dos Santos SE" Publisher international institute of anticancer research
2 results on '"Dos Santos SE"'

1. Population stratification effect on cancer susceptibility in an admixed population from Brazilian Amazon.

Author

Vieira PC, Burbano RM, Fernandes DC, Montenegro RC, Dos Santos SE, Sortica VA, Assumpção PP, Ribeiro-Dos-Santos ÂK, Carvalho AA, and Dos Santos NP

Subjects
Black People, Brazil, Breast Neoplasms pathology, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Polymorphism, Single Nucleotide, Risk Factors, Stomach Neoplasms pathology, White People, X-ray Repair Cross Complementing Protein 1, Breast Neoplasms genetics, DNA-Binding Proteins genetics, Genetics, Population, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Stomach Neoplasms genetics
Abstract

Background/aim: Many efforts have been made to identify candidate genes involved in cancer susceptibility. The present study aimed to investigate the association between Arg194Trp (XRCC1), Ala222Val (MTHFR) and Arg521Lys (EGFR) polymorphisms (SNPs) and their susceptibility to gastric and breast carcinoma cancer in patients from Brazilian Amazon, controlling population structure interference., Materials and Methods: The SNPs were genotyped by TaqMan® SNP Genotyping Assays. Ancestry was estimated by analysis of a panel with 48 ancestry informative markers., Results: Logistic regression analysis showed an inverse association with a 10% increase in African and European ancestry and cancer risk (odds ratio (OR)=1.919 and 0.676, respectively). In a preliminary Chi-square analysis a positive association between Arg521Lys (EGFR) polymorphism and carcinoma susceptibility was found (p=0.037); however, when two different methodologies to control population structure bias were utilized, this association was lost (p=0.064 and p=0.256)., Conclusion: Genetic ancestry influence gastric and breast cancer risk and highlight the importance of population structure inference in association studies in highly admixed populations, such as those from Brazilian Amazon., (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2015

2. Association of slow acetylation profile of NAT2 with breast and gastric cancer risk in Brazil.

Author

Fernandes MR, de Carvalho DC, dos Santos ÂK, dos Santos SE, de Assumpção PP, Burbano RM, and dos Santos NP

Subjects
Acetylation, Arylamine N-Acetyltransferase genetics, Base Sequence, Brazil, Breast Neoplasms genetics, Cohort Studies, DNA Primers, Female, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Risk Factors, Stomach Neoplasms genetics, Arylamine N-Acetyltransferase metabolism, Breast Neoplasms enzymology, Stomach Neoplasms enzymology
Abstract

Background: The N-acetyltransferase 2 (NAT2) gene is a marker for the study of interindividual susceptibility to developing neoplasias. The purpose of this study was to verify a possible association between single nucleotide polymomorphisms (SNPs) of NAT2 and the susceptibility to gastric cancer (GC) and breast cancer (BC) in patients from the North region of Brazil., Materials and Methods: Five SNPs of the NAT2 gene were investigated by direct sequencing. Ancestry was estimated by analysis of a panel with 48 ancestry-informative markers (AIM)., Results: Individuals with slow acetylation profile had an increased risk of developing neoplasias up to three times when compared to controls., Conclusion: In this study, slow acetylation profile was found to strongly influence susceptibility to GC and BC.

Published
2013

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