The purpose of this research is to determine the effect of house isolation on the Palestinian people's lifestyles, mental health (MW), and physical activity during the COVID-19 pandemic (PA). The Global Health Guidelines 5 and the Pittsburgh Sleep Quality Index, as well as the Food Frequency Questionnaire (FFQ) (PSQI) (PSQI), were used to collect demographic data. To collect data from all staff and students in Palestinian universities, including faculty and staff, as well as students, a non-discriminatory approach to community sampling was used, consisting of 360 research participants. According to the statistics, men are more likely than women to be in a good emotional state. By and large, people with improved mental states reported improved sleep quality and overall health. Increased physical activity (i.e. 17.33.6) was connected with improved mental health compared to average physical activity (i.e. 13.74.2). It has been proven that there is a relationship between a mental state variable and the amount of regular daily activity. Physical activity improves mental health. Additionally, physical exercise was the strongest predictor of mental health ratings.