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Organophosphorus insecticide (OPI) poisoning is a major health problem in India. These are irreversible inhibitors of acetyl cholinesterase which produce a well-established triphasic effect. The first phase which is a cholinergic phase due to increased action of acetylcholine at muscarinic, nicotinic and central nervous system synapses produces symptoms like Miosis, Blurred Vision, Nausea, Vomiting, Diarrhea, Salivation, Lacrimation, Bradycardia, Abdominal Pain (Muscarinic), Fasciculations, Paralysis, Pallor, Muscle Weakness, Hypertension, Tachycardia, Mydriasis (Nicotinic), Confusion, Toxic Psychosis, Seizure, Fatigue, Respiratory Depression, Dysarthria, Unconsciousness, Ataxia, Anxiety (Central Effects). The second phase is intermediate syndrome which sets in 2-4 days after initial exposure, the signs and symptoms comprise of muscle fasciculations and neuromuscular paralysis involving the respiratory, bulbar and limb muscles. The third phase is Organophosphorus Induced Delayed Polyneuropathy (OPIDN), which is often noted after 7-21 days of exposure, initial symptoms include paraesthesias, pain in calves, foot drop etc. In addition, extrapyramidal manifestations are also described after acute organophosphorus poisoning such as Dystonia, Rest Tremors, Cog Wheel Rigidity And Choreathetosis. Cypermethrin is a synthetic pyrethroid used as an insecticide. Studies suggested that long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats. Acute ingestion of cypermethrin will cause nausea, vomiting, stomach pain, convulsions, coma and death in humans. The etiology of parkinsonism is multi factorial with genetic, environmental and toxic determinants, development of typical parkinsonism after brief exposure to organophosphorus compounds is a rare phenomena and there are only few reports in literature. We report a 40 year old female who presented with cholinergic crisis following acute ingestion of Profofenos and Cypermethrin mixed compound, developed parkinsonism on day 5 of admission and recovered completely after 2 days of treatment with Amantidine. [ABSTRACT FROM AUTHOR]