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2 results on '"Ammonium paratungstate -- Health aspects"'

1. Hydrophobic Interaction Chromatography (HIC) for the Characterization of Therapeutic Monoclonal Antibodies and Related Products, Part 2: Practical Considerations

Author

Fekete, Szabolcs, Murisier, Amarande, Verscheure, Liesa, Sandra, Koen, and Guillarme, Davy

Subjects
Chromatography -- Health aspects, Ammonium compounds -- Health aspects, Biological products -- Health aspects, Ofatumumab -- Health aspects, Proteins -- Health aspects, Sulfates -- Health aspects, Phosphates -- Health aspects, Ammonium paratungstate -- Health aspects, Chemistry, Science and technology
Abstract

Hydrophobic interaction chromatography (HIC) is one of the historical analytical methods applied for the separation and purification of proteins. In the first part of this series, the elution and separation mechanisms were discussed. In this second part, some practical considerations such as method development, selection of the phase system, combined salt systems, and possibilities to combine HIC with other chromatographic modes are explained. Applications are critically discussed and the hyphenation to mass spectrometry (MS) briefly tackled., Historically, a kosmotropic salt--typically 1.5-2 M ammonium-sulfate--has been used as a mobile phase additive in hydrophobic interaction chromatography (HIC) (as well as 50-100 mM phosphate buffer). However, various salts can [...]

Published
2021

2. Advances in monoclonal antibody purification: new technologies and adaptations of existing technologies can improve platform processes

Author

Glynn, Judy, Boyle, Denis, Wealand, Jay, Miller-Cary, Erin, Chen, Brian, and Mensah, Paul

Subjects
Chromatography -- Health aspects, Rain and rainfall -- Health aspects, Ammonium chloride -- Health aspects, DNA -- Health aspects, Ammonium compounds -- Health aspects, Biological products -- Innovations -- Health aspects, Technology -- Health aspects, Protein binding -- Health aspects, Fatty acids -- Innovations -- Health aspects, Monoclonal antibodies -- Health aspects, Ammonium paratungstate -- Health aspects, Biotechnology industry, Business, Pharmaceuticals and cosmetics industries
Abstract

ABSTRACT Challenges in the purification of monoclonal antibodies (MAbs) include reducing production cost, developing robust processes for both product purity and viral clearance, and integrating upstream and downstream processes. Increases [...]

Published
2010

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