This chapter accounts for the synthesis and X-ray structure of selected imidazole derivatives: DMDPIMH: 4,5-dimethyl-1,2-diphenyl-1H-imidazole monohydrate, DMPPTI: 4,5-dimethyl-2-phenyl-1-(p-tolyl)-1H-imidazole, FPDMMPI: 2-(4-fluorophenyl)-4,5-dimethyl-1-(4-methylphenyl)-1H-imidazole, DMPDMPIHH: 1-(3,5-dimethylphenyl)-4,5-dimethyl-2-phenyl-1H-imidazole hemihydrate, DMPFPDMI: 1-(3,5-Dimethylphenyl)-2-(4-fluorophenyl)-4,5-dimethyl-1H-imidazole, FPMOPDMI: 2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4,5-dimethyl-1H-imidazole, DMOPFPDMI: 1-(3,5-dimethoxyphenyl)-2-(4-fluorophenyl)-4,5-dimethyl-1H-imidazole, and FPTPI: 2-(4-fluorophenyl)-1,4,5-triphenyl-1H-imidazole. The molecular crystal structure was determined by this investigation, along with the impact of substitutions on the geometry of the imidazole units. The uses and applications of the imidazole compounds are described in the introduction. All eight imidazole derivatives’ syntheses were discussed. The essential characteristics of the imidazole derivatives are provided by the structural analyses of the eight derivatives and a portion of a database survey. All the derivatives have a planar imidazole unit. The crystal structures are stabilized by intermolecular O▬H…N, O▬H…O, C▬H…N, hydrogen bonds, and C▬H…π interactions.