1. The Analogues of DNA Minor-Groove Binders as Antineoplastic Compounds
- Author
-
Danuta Drozdowska
- Subjects
Chemotherapy ,business.industry ,medicine.medical_treatment ,Drug resistance ,medicine.disease ,In vitro ,chemistry.chemical_compound ,Breast cancer ,chemistry ,Cancer research ,medicine ,Hormonal therapy ,Cytotoxic T cell ,skin and connective tissue diseases ,business ,DNA ,Minor groove - Abstract
Chemotherapy and hormonal therapy play important role in the treatment of breast cancer, a leading cause of cancer death in women. Although there are a lot of effective medicines applied, a significant number of patients do not respond to these therapeutic agents. Drug resistance, in addition to side effects of chemotherapy and hormonal therapy, necessitates the search for new specific tumor targeting compounds. Breast cancer cell lines have been widely used not only to investigate breast cancer pathobiology, but also to screen and characterize new therapeutics. Especially MCF-7 and MDA-MB-231 breast cancer cell lines often serve as in vitro models in cancer research. In this chapter, some of new compounds which showed antiproliferative and cytotoxic effects against MCF-7 and/or MBA-MB-231 breast cancer cell lines are presented.
- Published
- 2011