1. High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children.
- Author
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Orbe-Orihuela YC, Lagunas-Martínez A, Bahena-Román M, Madrid-Marina V, Torres-Poveda K, Flores-Alfaro E, Méndez-Padrón A, Díaz-Benítez CE, Peralta-Zaragoza O, Antúnez-Ortiz D, Cruz M, and Burguete-García AI
- Subjects
- Anthropometry, Bacteroides isolation & purification, Blood Glucose analysis, Child, Energy Intake, Exercise, Feces microbiology, Feeding Behavior, Female, Humans, Insulin blood, Interleukins blood, Lipids blood, Male, Firmicutes isolation & purification, Gastrointestinal Microbiome, Pediatric Obesity blood, Pediatric Obesity microbiology, Tumor Necrosis Factor-alpha blood
- Abstract
Objective: To investigate the correlation among pro- or anti-inflammatory cytokines and the two main gut microbiota phyla in obese children., Materials and Methods: Anthropometric data were obtained from 890 children under 14 years old to determine the degree of obesity. Serum cytokine concentration was measured by ELISA. Relative abundance of gut microbiota in feces was evaluated by quantitative RealTime PCR assays., Results: Anthropometric and biochemical parameters were statistically higher in overweigth/ obese children (OW/O) than in lean (NW), Increased TNF-α levels were found in obese children that also have a high relative abundance of Firmicutes., Conclusions: Obese children have a high relative abundance of Firmicutes that correlates with increased levels of TNF-α. This is the first study that shows a relation between Firmicute abundance and TNF-α serum concentration in obese children., Competing Interests: Declaration of conflict of interests. The authors declare that they have no conflict of interests.
- Published
- 2018
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