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Start Over Author "Tamayo , Liliana" Publisher instituto nacional de salud
6 results on '"Tamayo , Liliana"'

1. Correlation between disease severity indices and quality of life measurement tools in atopic dermatitis

Author

Sanclemente, Gloria, Hernández , Natalia, Tamayo , Liliana, Chaparro, Daniela, López , Ángela, Research Group , Colombian Atopic Dermatitis, Sanclemente, Gloria, Hernández , Natalia, Tamayo , Liliana, Chaparro, Daniela, López , Ángela, and Research Group , Colombian Atopic Dermatitis

Abstract

Introduction. Reports regarding the correlation and effect size of change of the full spectrum of quality of life (QOL) and disease severity measures applied in-person to patients with atopic dermatitis, are scarce. Objectives. To assess QOL with 3 different instruments and to evaluate disease severity indices and to determine their correlation and effect size of change between two measurements.Materials and methods. Patient-level data were obtained through two in-person visits. Sociodemographic information and data related to disease distribution, disease severity (through the BSA, EASI, SCORAD, POEM, itching) and the impact of AD on QoL using the DLQI and Skindex-29 and EQ5D, were assessed. The correlation between change in QOL scores and change in disease severity scores in addition to the standardized effect size were also evaluated.Results. Only 139 out of 212 patients, completed the follow-up visit. BSA highly correlated with SCORAD and EASI, and the lowest correlation was found with POEM. The best correlation of pruritus VAS was found with sleep disturbance. The SCORAD score highly correlated with EASI and the lowest correlation was found with POEM. The magnitude of the effect at initiation of the study vs follow-up was in average moderate to important. Conclusions. Patients with AD experience a substantial burden in quality of life. Disease activity correlates better with QoL measurements when the disease is less severe after starting therapy. POEM and Skindex-29 seem to be optimal to determine disease severity and QoL in adults with atopic dermatitis., ntroducción. La información publicada acerca de la correlación y el tamaño del efecto del cambio de todo el espectro de la medida de la calidad de vida (QOL) y de la gravedad de la enfermedad aplicadas en persona a pacientes con dermatitis atópica son escasos.Objetivos. Evaluar la calidad de vida con 3 instrumentos diferentes y evaluar los índices de gravedad de la enfermedad y determinar su correlación y el tamaño del efecto del cambio entre dos mediciones.Materiales y métodos. Los datos de los pacientes se obtuvieron a través de dos visitas en persona. Se evaluó la información sociodemográfica y los datos relacionados con la distribución de la enfermedad, la gravedad de la enfermedad (a través de BSA, EASI, SCORAD, POEM, prurito) y el impacto de la DA en la calidad de vida utilizando el DLQI y Skindex-29 y EQ5D. También se evaluó la correlación entre el cambio en las puntuaciones de calidad de vida y el cambio en las puntuaciones de gravedad de la enfermedad, además del tamaño del efecto estandarizado.Resultados. Solo 139 de 212 pacientes completaron la visita de seguimiento. El área de superficie corporal se correlacionó altamente con el SCORAD y el EASI, y la correlación más baja se encontró con el POEM. La mejor correlación del prurito medido con la escala visual análoga se halló con la alteración del sueño. El puntaje SCORAD se correlacionó altamente con el EASI y la correlación más baja se encontró con el POEM. La magnitud del efecto al inicio del estudio frente al seguimiento fue en promedio de moderada a importante.Conclusiones. Los pacientes con DA experimentan una carga sustancial en la calidad de vida. La actividad de la enfermedad se correlaciona mejor con las mediciones de calidad de vida cuando la enfermedad es menos grave después de comenzar la terapia. El POEM y el Skindex-29 parecen ser óptimos para determinar la gravedad de la enfermedad y la calidad de vida en adultos con dermatitis atópica.

Published
2024

2. Omalizumab: opción terapéutica para la urticaria crónica espontánea de difícil control con vasculitis asociada, reporte de tres casos

Author

Díez, Libia Susana, Tamayo, Liliana María, and Cardona, Ricardo

Subjects
histamine antagonists, urticaria, antagonistas de leucotrieno, antagonistas de los receptores histamínicos, leukotriene antagonists, factores inmunológicos, immunologic factors, vasculitis
Abstract

Introducción. Aproximadamente el 50 % de los casos de urticaria crónica no mejoran adecuadamente con las dosis convencionales de antihistamínicos, por lo cual se han planteado múltiples opciones terapéuticas, entre las cuales el omalizumab es una herramienta novedosa que ahora cuenta con evidencia de alta calidad que soporta su uso en los casos difíciles, que mejora rápidamente el índice sintomático y el uso de medicamentos, y cuenta con un buen perfil de seguridad. Objetivo. Presentar tres casos de mujeres adultas con urticaria crónica espontánea de más de ocho años de evolución, que no mejoraron con el tratamiento con altas dosis de antihistamínicos, asociados a antileucotrienos e inmunomoduladores y en quienes se combinaban varios mecanismos fisiopatológicos: urticaria crónica espontánea con componente de autoinmunidad, componente de presión y urticaria vasculítica. Materiales y métodos. Se reportan los casos con sus respectivas evaluaciones clínicas y de laboratorio, los medicamentos usados y la respuesta después del inicio de omalizumab y se hace una revisión de la literatura científica sobre uso de este medicamento en la urticaria crónica. Resultados. En los tres casos presentados se obtuvo una mejoría completa de los síntomas tras el inicio del omalizumab. Conclusión. El omalizumab es una opción terapéutica exitosa en casos de urticaria crónica de difícil control con vasculitis asociada, cuando se han agotado las opciones propuestas por las guías internacionales. Introduction: Approximately 50% of chronic urticaria cases do not respond adequately to conventional doses of antihistamines, so a number of other therapeutic options have been suggested. Among these, omalizumab is an innovative tool, which now has high-quality evidence that supports its use in difficult cases, rapidly improving the symptom index and the use of medications with a good safety profile. Objective: To report three cases of adult women with spontaneous chronic urticaria with an evolution of more than eight years, which did not improve with high doses of antihistamines and leukotriene receptor blockers, associated with immunomodulatory therapy in which several etiologic mechanisms were combined: chronic spontaneous urticaria with autoimmune and pressure components, and vasculitis. Materials and methods: We report the cases with their clinical and laboratory evaluations, used medication, the response after the start of omalizumab and we performed a review of the literature on the use of this drug in chronic urticaria. Results: In all the presented cases, we obtained complete improvement of symptoms after starting omalizumab. Conclusion: Omalizumab is a successful treatment option in cases of difficult to control chronic urticaria with associated vasculitis in which the options proposed by international guidelines have been exhausted.

Published
2013

3. Urticaria por frío: serie de casos y revisión del tema

Author

Sánchez, Jorge Mario, Ramírez, Ruth Helena, Tamayo, Liliana María, Chinchilla, Carlos Fernando, and Cardona, Ricardo

Subjects
histamine antagonists, urticaria, crioglobulinemia, angioedema, frío, anaphylaxis, antagonistas de histamina, anafilaxia, cryoglobulinemia, cold temperatura
Abstract

La urticaria por frío es una de las cinco causas más frecuentes de urticarias crónicas; está incluida en el grupo de urticarias físicas y puede ocurrir luego de la exposición al frío, ya sea a través de un objeto, el aire o un líquido. Los pacientes pueden presentar síntomas de urticaria, angioedema, dificultad respiratoria e, incluso, anafilaxia al sacar objetos de la nevera, nadar en agua fría o al entrar a cuartos con aire acondicionado. A continuación se presentan cinco pacientes con diagnóstico de esta enfermedad y una breve revisión del tema. Cold urticaria is one of the five most common causes of chronic urticaria and is grouped as a physical urticaria. It can occur after exposure to cold, either through solid objects, air or liquids. Patients may have symptoms of urticaria, angioedema, respiratory distress and even anaphilaxis when the skin is exposed to a cold environment, such as handling refrigerated objects, swimming in cold water or entering an air-conditioned room. Five cases of cold urticaria are presented, followed by a brief literature review.

Published
2011

4. Correlation between disease severity indices and quality of life measurement tools in atopic dermatitis patients

Author

Sanclemente G, Hernández N, Tamayo L, Chaparro D, López Á, and Research Group CAD

Subjects
Humans, Adult, Male, Female, Middle Aged, Pruritus etiology, Young Adult, Dermatitis, Atopic psychology, Quality of Life, Severity of Illness Index
Abstract

Introduction: Reports regarding the correlation and effect size of change of the full spectrum of quality of life and disease severity measures applied in-person to patients with atopic dermatitis are scarce., Objectives: To assess quality-of-life with 3 different instruments and to evaluate disease severity indices and to determine their correlation and effect size of change between two measurements., Materials and Methods: Patient-level data were obtained through two in-person visits. Sociodemographic information and data related to disease distribution, severity (through the BSA, EASI, SCORAD, POEM, and itching scales), and the impact of atopic dermatitis on quality of life using the DLQI and Skindex-29, and EQ-5D, were assessed. The correlation between change in quality-of-life scores and disease severity scores in addition to the standardized effect size were also evaluated., Results: Only 139 out of 212 patients completed the follow-up visit. BSA highly correlated with SCORAD and EASI, and the lowest correlation was found with POEM. The best correlation of pruritus VAS was found with sleep disturbance. The SCORAD score highly correlated with EASI, and the lowest correlation was found with POEM. The magnitude of the effect at initiation of the study vs follow-up was in average moderate to important., Conclusions: Patients with atopic dermatitis experience a substantial burden on quality of life. Disease activity correlates better with quality-of-life measurements when the disease is less severe after starting therapy. POEM and Skindex-29 seem to be optimal to determine disease severity and quality of life in adults with atopic dermatitis.

Published
2024
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5. [Omalizumab: therapeutic option in chronic spontaneous urticaria difficult to control with associated vasculitis, report of three cases].

Author

Díez LS, Tamayo LM, and Cardona R

Subjects
Adult, Chronic Disease, Female, Humans, Middle Aged, Omalizumab, Anti-Allergic Agents therapeutic use, Antibodies, Anti-Idiotypic therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Urticaria complications, Urticaria drug therapy, Vasculitis complications
Abstract

Introduction: Approximately 50% of chronic urticaria cases do not respond adequately to conventional doses of antihistamines, so a number of other therapeutic options have been suggested. Among these, omalizumab is an innovative tool, which now has high-quality evidence that supports its use in difficult cases, rapidly improving the symptom index and the use of medications with a good safety profile., Objective: To report three cases of adult women with spontaneous chronic urticaria with an evolution of more than eight years, which did not improve with high doses of antihistamines and leukotriene receptor blockers, associated with immunomodulatory therapy in which several etiologic mechanisms were combined: chronic spontaneous urticaria with autoimmune and pressure components, and vasculitis., Materials and Methods: We report the cases with their clinical and laboratory evaluations, used medication, the response after the start of omalizumab and we performed a review of the literature on the use of this drug in chronic urticaria., Results: In all the presented cases, we obtained complete improvement of symptoms after starting omalizumab., Conclusion: Omalizumab is a successful treatment option in cases of difficult to control chronic urticaria with associated vasculitis in which the options proposed by international guidelines have been exhausted.

Published
2013
Full Text
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6. [Cold urticaria: case series and literature review].

Author

Sánchez JM, Ramírez RH, Tamayo LM, Chinchilla CF, and Cardona R

Subjects
Adult, Child, Preschool, Female, Humans, Male, Urticaria diagnosis, Urticaria pathology, Urticaria physiopathology, Cold Temperature, Urticaria etiology
Abstract

Cold urticaria is one of the five most common causes of chronic urticaria and is grouped as a physical urticaria. It can occur after exposure to cold, either through solid objects, air or liquids. Patients may have symptoms of urticaria, angioedema, respiratory distress and even anaphylaxis when the skin is exposed to a cold environment, such as handling refrigerated objects, swimming in cold water or entering an air-conditioned room. Five cases of cold urticaria are presented, followed by a brief literature review.

Published
2011
Full Text
View/download PDF

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