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12 results on '"Cirrone, G."'

1. Proton Computed Tomography: Iterative image reconstruction and dose evaluation

Author

Civinini, C, Bonanno, D, Brianzi, M, Carpinelli, M, Cirrone, G, Cuttone, G, Presti, D, Maccioni, G, Pallotta, S, Randazzo, N, Scaringella, M, Romano, F, Sipala, V, Talamonti, C, Vanzi, E, Bruzzi, M, Bonanno, D., Brianzi, M., CARPINELLI, Massimo, Cirrone, G. A. P., Cuttone, G., Presti, D. Lo, Maccioni, G., Pallotta, S., Randazzo, N., Scaringella, M., Romano, F., SIPALA, Valeria, Talamonti, C., Vanzi, E., Bruzzi, M., Civinini, C, Bonanno, D, Brianzi, M, Carpinelli, M, Cirrone, G, Cuttone, G, Presti, D, Maccioni, G, Pallotta, S, Randazzo, N, Scaringella, M, Romano, F, Sipala, V, Talamonti, C, Vanzi, E, Bruzzi, M, Bonanno, D., Brianzi, M., CARPINELLI, Massimo, Cirrone, G. A. P., Cuttone, G., Presti, D. Lo, Maccioni, G., Pallotta, S., Randazzo, N., Scaringella, M., Romano, F., SIPALA, Valeria, Talamonti, C., Vanzi, E., and Bruzzi, M.

Abstract

Proton Computed Tomography (pCT) is a medical imaging method with a potential for increasing accuracy of treatment planning and patient positioning in hadron therapy. A pCT system based on a Silicon microstrip tracker and a YAG:Ce crystal calorimeter has been developed within the INFN Prima-RDH collaboration. The prototype has been tested with a 175 MeV proton beam at The Svedberg Laboratory (Uppsala, Sweden) with the aim to reconstruct and characterize a tomographic image. Algebraic iterative reconstruction methods (ART), together with the most likely path formalism, have been used to obtain tomographies of an inhomogeneous phantom to eventually extract density and spatial resolutions. These results will be presented and discussed together with an estimation of the average dose delivered to the phantom and the dependence of the image quality on the dose. Due to the heavy computation load required by the algebraic algorithms the reconstruction programs have been implemented to fully exploit the high calculation parallelism of Graphics Processing Units. An extended field of view pCT system is in an advanced construction stage. This apparatus will be able to reconstruct objects of the size of a human head making possible to characterize this pCT approach in a pre-clinical environment.

Published
2017

2. Design and characterisation of a YAG(Ce) calorimeter for proton Computed Tomography application

Author

Sipala, V, Randazzo, N, Aiello, S, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Leonora, E, Lo Presti, D, Pallotta, S, Pugliatti, C, Scaringella, M, Stancampiano, C, Talamonti, C, Vanzi, E, SIPALA, Valeria, Randazzo, N., Aiello, S., Bruzzi, M., Bucciolini, M., CARPINELLI, Massimo, Cirrone, G. A. P., Civinini, C., Cuttone, G., Leonora, E., Lo Presti, D., Pallotta, S., Pugliatti, C., Scaringella, M., Stancampiano, C., Talamonti, C., Vanzi, E., Sipala, V, Randazzo, N, Aiello, S, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Leonora, E, Lo Presti, D, Pallotta, S, Pugliatti, C, Scaringella, M, Stancampiano, C, Talamonti, C, Vanzi, E, SIPALA, Valeria, Randazzo, N., Aiello, S., Bruzzi, M., Bucciolini, M., CARPINELLI, Massimo, Cirrone, G. A. P., Civinini, C., Cuttone, G., Leonora, E., Lo Presti, D., Pallotta, S., Pugliatti, C., Scaringella, M., Stancampiano, C., Talamonti, C., and Vanzi, E.

Abstract

The design and the characterization of a calorimeter system, aimed at measuring the residual energy in a proton Computed Tomography (pCT) apparatus, is described. The calorimeter has a 6×6cm2 active area to fully cover the tracker area of the pCT system, being 10 cm thick it is able to stop up to 200 MeV protons and sustain 1MHz particle rate (average rate on the whole area). The YAG(Ce) scintillator is promising for charged particle detection applications where high-count rate, good energy resolution and compact photodiode readout, not influenced by magnetic fields, are of importance. The aim of this work is to show data acquired with proton beam energy up to 175 MeV and to discuss the performances of this calorimeter.

Published
2015

3. A new Thomson Spectrometer for high energy laser-driven beams diagnostic

Author

Cirrone, G, Tramontan, A, Candiano, G, Carpinelli, M, Cavallaro, S, Cutroneo, M, Cuttone, G, De Martinis, C, Giove, D, Krasa, J, Korn, G, Maggiore, M, Margarone, D, Pisciotta, P, Prokupek, J, Romano, F, Schillaci, F, Scuderi, V, Torrisi, L, Velyhan, A, Cirrone G. A. P., Tramontan A., Candiano G., CARPINELLI, Massimo, Cavallaro S., Cutroneo M., Cuttone G., De Martinis C., Giove D., Krasa J., Korn G., Maggiore M., Margarone D., Pisciotta P., Prokupek J., Romano F., Schillaci F., Scuderi V., Torrisi L., Velyhan A., Cirrone, G, Tramontan, A, Candiano, G, Carpinelli, M, Cavallaro, S, Cutroneo, M, Cuttone, G, De Martinis, C, Giove, D, Krasa, J, Korn, G, Maggiore, M, Margarone, D, Pisciotta, P, Prokupek, J, Romano, F, Schillaci, F, Scuderi, V, Torrisi, L, Velyhan, A, Cirrone G. A. P., Tramontan A., Candiano G., CARPINELLI, Massimo, Cavallaro S., Cutroneo M., Cuttone G., De Martinis C., Giove D., Krasa J., Korn G., Maggiore M., Margarone D., Pisciotta P., Prokupek J., Romano F., Schillaci F., Scuderi V., Torrisi L., and Velyhan A.

Abstract

Thomson Spectrometers (TPs) are widely used for beam diagnostic as they provide simultaneous information on charge over mass ratio, energy and momentum of detected ions. A new TP design has been realized at INFN-LNS within the LILIA (Laser Induced Light Ion Acceleration) and ELIMED (MEDical application at ELI-Beamlines) projects. This paper reports on the construction details of the TP and on its experimental tests performed at PALS laboratory in Prague, with the ASTERIX IV laser system. Reported data are obtained with polyethylene and polyvinyl alcohol solid targets, they have been compared with data obtained from other detectors. Consistency among results confirms the correct functioning of the new TP. The main features, characterizing the design, are a wide acceptance of the deflection sector and a tunability of the, partially overlapping, magnetic and electric fields that allow to resolve ions with energy up to about 40 MeV for protons.

Published
2014

4. ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines

Author

Schillaci, F, Anzalone, A, Cirrone, G, Carpinelli, M, Cuttone, G, Cutroneo, M, De Martinis, C, Giove, D, Korn, G, Maggiore, M, Manti, L, Margarone, D, Musumarra, A, Perozziello, F, Petrovic, I, Pisciotta, P, Renis, M, Ristic Fira, A, Romano, F, Schettino, G, Scuderi, V, Torrisi, L, Tramontana, A, Tudisco, S, Schillaci F., Anzalone A., Cirrone G. A. P., CARPINELLI, Massimo, Cuttone G., Cutroneo M., De Martinis C., Giove D., Korn G., Maggiore M., Manti L., Margarone D., Musumarra A., Perozziello F. M., Petrovic I., Pisciotta P., Renis M., Ristic Fira A., Romano F., Romano F. P., Schettino G., Scuderi V., Torrisi L., Tramontana A., Tudisco S., Schillaci, F, Anzalone, A, Cirrone, G, Carpinelli, M, Cuttone, G, Cutroneo, M, De Martinis, C, Giove, D, Korn, G, Maggiore, M, Manti, L, Margarone, D, Musumarra, A, Perozziello, F, Petrovic, I, Pisciotta, P, Renis, M, Ristic Fira, A, Romano, F, Schettino, G, Scuderi, V, Torrisi, L, Tramontana, A, Tudisco, S, Schillaci F., Anzalone A., Cirrone G. A. P., CARPINELLI, Massimo, Cuttone G., Cutroneo M., De Martinis C., Giove D., Korn G., Maggiore M., Manti L., Margarone D., Musumarra A., Perozziello F. M., Petrovic I., Pisciotta P., Renis M., Ristic Fira A., Romano F., Romano F. P., Schettino G., Scuderi V., Torrisi L., Tramontana A., and Tudisco S.

Abstract

ELI-Beamlines is one of the pillars of the pan-European project ELI (Extreme Light Infrastructure). It will be an ultra high-intensity, high repetition-rate, femtosecond laser facility whose main goal is generation and applications of high-brightness X-ray sources and accelerated charged particles in different fields. Particular care will be devoted to the potential applicability of laser-driven ion beams for medical treatments of tumors. Indeed, such kind of beams show very interesting peculiarities and, moreover, laser-driven based accelerators can really represent a competitive alternative to conventional machines since they are expected to be more compact in size and less expensive. The ELIMED project was launched thanks to a collaboration established between FZU-ASCR (ELI-Beamlines) and INFN-LNS researchers. Several European institutes have already shown a great interest in the project aiming to explore the possibility to use laser-driven ion (mostly proton) beams for several applications with a particular regard for medical ones. To reach the project goal several tasks need to be fulfilled, starting from the optimization of laser-target interaction to dosimetric studies at the irradiation point at the end of a proper designed transport beam-line. Researchers from LNS have already developed and successfully tested a high-dispersive power Thomson Parabola Spectrometer, which is the first prototype of a more performing device to be used within the ELIMED project. Also a Magnetic Selection System able to produce a small pencil beam out of a wide energy distribution of ions produced in laser-target interaction has been realized and some preliminary work for its testing and characterization is in progress. In this contribution the status of the project will be reported together with a short description of the of the features of device recently developed.

Published
2014

5. A proton Computed Tomography based medical imaging system

Author

Scaringella, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Vanzi, E, Zani, M, Scaringella M., Bruzzi M., Bucciolini M., CARPINELLI, Massimo, Cirrone G. A. P., Civinini C., Cuttone G., Lo Presti D., Pallotta S., Pugliatti C., Randazzo N., Romano F., SIPALA, Valeria, Stancampiano C., Talamonti C., Vanzi E., Zani M., Scaringella, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Vanzi, E, Zani, M, Scaringella M., Bruzzi M., Bucciolini M., CARPINELLI, Massimo, Cirrone G. A. P., Civinini C., Cuttone G., Lo Presti D., Pallotta S., Pugliatti C., Randazzo N., Romano F., SIPALA, Valeria, Stancampiano C., Talamonti C., Vanzi E., and Zani M.

Abstract

This paper reports on the activity of the INFN PRIMA/RDH collaboration in the development of proton Computed Tomography (pCT) systems based on single proton tracking and residual energy measurement. The systems are made of a silicon microstrip tracker and a YAG:Ce crystal calorimeter to measure single protons trajectory and residual energy, respectively. A first prototype of pCT scanner, with an active area of about 5 × 5 cm2 and a data rate capability of 10 kHz, has been constructed and characterized with 62 MeV protons at INFN Laboratori Nazionali del Sud in Catania (Italy) and with 180 MeV protons at The Svedberg Laboratory (TSL) in Uppsala (Sweden). Results of these measurements, including tomographic reconstructions of test phantoms, will be shown and discussed. An upgraded system with an extended field of view (up to ∼ 5 × 20 cm2) and an increased event rate capability up to one MHz, presently under development, will be also described.

Published
2014

6. Medical research and multidisciplinary applications with laser-accelerated beams: The ELIMED netwotk at ELI-Beamlines

Author

Tramontana, A, Anzalone, A, Candiano, G, Carpinelli, M, Cirrone, G, Cuttone, G, Korn, G, Licciardello, T, Maggiore, M, Manti, L, Margarone, D, Musumarra, A, Perozziello, F, Pisciotta, P, Raffaele, L, Romano, F, Stancampiano, C, Schillaci, F, Scuderi, V, Torrisi, L, Tudiscob, S, Tramontana A., Anzalone A., Candiano G., CARPINELLI, Massimo, Cirrone G. A. P., Cuttone G., Korn G., Licciardello T., Maggiore M., Manti L., Margarone D., Musumarra A., Perozziello F., Pisciotta P., Raffaele L., Romano F., Romano F. P., Stancampiano C., Schillaci F., Scuderi V., Torrisi L., Tudiscob S., Tramontana, A, Anzalone, A, Candiano, G, Carpinelli, M, Cirrone, G, Cuttone, G, Korn, G, Licciardello, T, Maggiore, M, Manti, L, Margarone, D, Musumarra, A, Perozziello, F, Pisciotta, P, Raffaele, L, Romano, F, Stancampiano, C, Schillaci, F, Scuderi, V, Torrisi, L, Tudiscob, S, Tramontana A., Anzalone A., Candiano G., CARPINELLI, Massimo, Cirrone G. A. P., Cuttone G., Korn G., Licciardello T., Maggiore M., Manti L., Margarone D., Musumarra A., Perozziello F., Pisciotta P., Raffaele L., Romano F., Romano F. P., Stancampiano C., Schillaci F., Scuderi V., Torrisi L., and Tudiscob S.

Abstract

Laser accelerated proton beams represent nowadays an attractive alternative to the conventional ones and they have been proposed in different research fields. In particular, the interest has been focused in the possibility of replacing conventional accelerating machines with laser-based accelerators in order to develop a new concept of hadrontherapy facilities, which could result more compact and less expensive. With this background the ELIMED (ELIMED: ELI-Beamlines MEDical applications) research project has been launched by LNS-INFN researchers (Laboratori Nazionali del Sud-Istituto Nazionale di Fisica Nucleare, Catania, IT) and ASCR-FZU researchers (Academy of Sciences of the Czech Republic-Fyzikální ústar, Prague, Cz), within the pan-European ELI-Beamlines facility framework. Its main purposes are the demonstration of future applications in hadrontherapy of optically accelerated protons and the realization of a laser-accelerated ion transport beamline for multidisciplinary applications. Several challenges, starting from laser-target interaction and beam transport development, up to dosimetric and radiobiological issues, need to be overcome in order to reach the final goals. The design and the realization of a preliminary beam handling and dosimetric system and of an advanced spectrometer for high energy (multi-MeV) laser-accelerated ion beams will be shortly presented in this work.

Published
2014

7. The Energy Selection System for the laser-accelerated proton beams at ELI-Beamlines

Author

Tramontana, A, Candiano, G, Carpinelli, M, Cirrone, G, Cuttone, G, Jia, S, Korn, G, Licciardello, T, Maggiore, M, Manti, L, Margarone, D, Pisciotta, P, Romano, F, Stancampiano, C, Schillaci, F, Scuderi, V, Cirrone, GAP, Jia, SB, Tramontana, A, Candiano, G, Carpinelli, M, Cirrone, G, Cuttone, G, Jia, S, Korn, G, Licciardello, T, Maggiore, M, Manti, L, Margarone, D, Pisciotta, P, Romano, F, Stancampiano, C, Schillaci, F, Scuderi, V, Cirrone, GAP, and Jia, SB

Abstract

ELI-Beamlines is one of the four pillars of the ELI (Extreme Light Infrastructure) pan-European project. It will be an ultrahigh-intensity, high repetition-rate, femtosecond laser facility whose main goals are the generation and applications of high-brightness X-ray sources and accelerated charged particles. In particular medical and multidisciplinary applications with laser-accelerated beams are treated by the ELIMED task force, a collaboration between different research institutes. A crucial goal for this network is represented by the design and the realization of a transport beamline able to provide ion beams with suitable characteristics in terms of energy spectrum and angular distribution in order to perform dosimetric tests and biological cell irradiations. A first prototype of transport beamline has been already designed and some magnetic elements are already under construction. In particular, an Energy Selector System (ESS) prototype has been already realized at LNS-INFN. This paper reports about the studies of the ESS properties as, for instance, energy spread and transmission efficiency, carried out using the GEANT4 Monte Carlo code.

Published
2014

8. A proton Computed Tomography system for medical applications

Author

Sipala, V, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, SIPALA, Valeria, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Sipala, V, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, SIPALA, Valeria, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, and Zani M.

Abstract

Proton Computed Tomography (pCT) can improve the accuracy of both patient positioning and dose calculation in proton therapy, enabling to accurately reconstruct the electron density distribution of irradiated tissues. A pCT prototype, equipped with a silicon tracker and a YAG:Ce calorimeter, has been manufactured by an Italian collaboration. First tests under proton beam allowed obtaining good quality tomographic images of a non-homogeneous phantom. Manufacturing of a new large area system with real-time data acquisition is under way.

Published
2013

9. FIRST experiment: Fragmentation of ions relevant for space and therapy

Author

Agodi, C, Abou Haidar, Z, Alvarez, M, Aumann, T, Balestra, F, Battistoni, G, Bocci, A, Bohlen, T, Bondi, M, Boudard, A, Brunetti, A, Carpinelli, M, Cappuzzello, F, Cavallaro, M, Carbone, D, Cirrone, G, Cortes Giraldo, M, Cuttone, G, De Napoli, M, Durante, M, Fernandez Garcia, J, Finck, C, Foti, A, Gallardo, M, Golosio, B, Iarocci, E, Iazzi, F, Ickert, G, Introzzi, R, Juliani, D, Krimmer, J, Kurz, N, Labalme, M, Lavagno, A, Leifels, Y, Le Fevre, A, Leray, S, Marchetto, F, Monaco, V, Morone, M, Nicolosi, D, Oliva, P, Paoloni, A, Patera, V, Piersanti, L, Pleskac, R, Quesada, J, Randazzo, N, Romano, F, Rossi, D, Rosso, V, Rousseau, M, Sacchi, R, Sala, P, Sarti, A, Scheidenberger, C, Schuy, C, Sciubba, A, Sfienti, C, Simon, H, Sipala, V, Spiriti, E, Stuttge, L, Tropea, S, Younis, H, Agodi C, Abou Haidar Z, Alvarez MAG, Aumann T, Balestra F, Battistoni G, Bocci A, Bohlen TT, Bondi M, Boudard A, BRUNETTI, Antonio, CARPINELLI, Massimo, Cappuzzello F, Cavallaro M, Carbone D, Cirrone GAP, Cortes Giraldo MA, Cuttone G, De Napoli M, Durante M, Fernandez Garcia JP, Finck C, Foti A, Gallardo MI, GOLOSIO, Bruno, Iarocci E, Iazzi F, Ickert G, Introzzi R, Juliani D, Krimmer J, Kurz N, Labalme M, Lavagno A, Leifels Y, Le Fevre A, Leray S, Marchetto F, Monaco V, Morone MC, Nicolosi D, OLIVA, Piernicola, Paoloni A, Patera V, Piersanti L, Pleskac R, Quesada JM, Randazzo N, Romano F, Rossi D, Rosso V, Rousseau M, Sacchi R, Sala P, Sarti A, Scheidenberger C, Schuy C, Sciubba A, Sfienti C, Simon H, SIPALA, Valeria, Spiriti E, Stuttge L, Tropea S, Younis H., Agodi, C, Abou Haidar, Z, Alvarez, M, Aumann, T, Balestra, F, Battistoni, G, Bocci, A, Bohlen, T, Bondi, M, Boudard, A, Brunetti, A, Carpinelli, M, Cappuzzello, F, Cavallaro, M, Carbone, D, Cirrone, G, Cortes Giraldo, M, Cuttone, G, De Napoli, M, Durante, M, Fernandez Garcia, J, Finck, C, Foti, A, Gallardo, M, Golosio, B, Iarocci, E, Iazzi, F, Ickert, G, Introzzi, R, Juliani, D, Krimmer, J, Kurz, N, Labalme, M, Lavagno, A, Leifels, Y, Le Fevre, A, Leray, S, Marchetto, F, Monaco, V, Morone, M, Nicolosi, D, Oliva, P, Paoloni, A, Patera, V, Piersanti, L, Pleskac, R, Quesada, J, Randazzo, N, Romano, F, Rossi, D, Rosso, V, Rousseau, M, Sacchi, R, Sala, P, Sarti, A, Scheidenberger, C, Schuy, C, Sciubba, A, Sfienti, C, Simon, H, Sipala, V, Spiriti, E, Stuttge, L, Tropea, S, Younis, H, Agodi C, Abou Haidar Z, Alvarez MAG, Aumann T, Balestra F, Battistoni G, Bocci A, Bohlen TT, Bondi M, Boudard A, BRUNETTI, Antonio, CARPINELLI, Massimo, Cappuzzello F, Cavallaro M, Carbone D, Cirrone GAP, Cortes Giraldo MA, Cuttone G, De Napoli M, Durante M, Fernandez Garcia JP, Finck C, Foti A, Gallardo MI, GOLOSIO, Bruno, Iarocci E, Iazzi F, Ickert G, Introzzi R, Juliani D, Krimmer J, Kurz N, Labalme M, Lavagno A, Leifels Y, Le Fevre A, Leray S, Marchetto F, Monaco V, Morone MC, Nicolosi D, OLIVA, Piernicola, Paoloni A, Patera V, Piersanti L, Pleskac R, Quesada JM, Randazzo N, Romano F, Rossi D, Rosso V, Rousseau M, Sacchi R, Sala P, Sarti A, Scheidenberger C, Schuy C, Sciubba A, Sfienti C, Simon H, SIPALA, Valeria, Spiriti E, Stuttge L, Tropea S, and Younis H.

Abstract

Nuclear fragmentation processes are relevant in different fields of basic research and applied physics and are of particular interest for tumor therapy and for space radiation protection applications. The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at SIS accelerator of GSI laboratory in Darmstadt, has been designed for the measurement of different ions fragmentation cross sections at different energies between 100 and 1000 MeV/nucleon. The experiment is performed by an international collaboration made of institutions from Germany, France, Italy and Spain. The experimental apparatus is partly based on an already existing setup made of the ALADIN magnet, the MUSIC IV TPC, the LAND2 neutron detector and the TOFWALL scintillator TOF system, integrated with newly designed detectors in the interaction Region (IR) around the carbon removable target: a scintillator Start Counter, a Beam Monitor drift chamber, a silicon Vertex Detector and a Proton Tagger for detection of light fragments emitted at large angles (KENTROS). The scientific program of the FIRST experiment started on summer 2011 with the study of the 400 MeV/nucleon 12C beam fragmentation on thin (8mm) carbon target.

Published
2013

10. Proton Computed Tomography: Iterative image reconstruction and dose evaluation

Author

E. Vanzi, M. Carpinelli, M. Brianzi, G.A.P. Cirrone, N. Randazzo, Danilo Bonanno, C. Civinini, Mara Bruzzi, G. Maccioni, Fabrizio Romano, D. Lo Presti, Valeria Sipala, Cinzia Talamonti, Stefania Pallotta, Monica Scaringella, Giacomo Cuttone, Civinini, C, Bonanno, D, Brianzi, M, Carpinelli, M, Cirrone, G, Cuttone, G, Presti, D, Maccioni, G, Pallotta, S, Randazzo, N, Scaringella, M, Romano, F, Sipala, V, Talamonti, C, Vanzi, E, and Bruzzi, M

Subjects
medicine.medical_specialty, Image quality, Image processing, Iterative reconstruction, 01 natural sciences, Imaging phantom, The Svedberg Laboratory, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Instrumentation for hadron therapy, 0103 physical sciences, Medical imaging, medicine, Computer vision, Medical physics, Instrumentation, Image resolution, Mathematical Physics, Physics, 010308 nuclear & particles physics, business.industry, Artificial intelligence, Tomography, Medical-image reconstruction methods and algorithms, computer-aided software, Instrumentation for particle-beam therapy, business
Abstract

Proton Computed Tomography (pCT) is a medical imaging method with a potential for increasing accuracy of treatment planning and patient positioning in hadron therapy. A pCT system based on a Silicon microstrip tracker and a YAG:Ce crystal calorimeter has been developed within the INFN Prima-RDH collaboration. The prototype has been tested with a 175 MeV proton beam at The Svedberg Laboratory (Uppsala, Sweden) with the aim to reconstruct and characterize a tomographic image. Algebraic iterative reconstruction methods (ART), together with the most likely path formalism, have been used to obtain tomographies of an inhomogeneous phantom to eventually extract density and spatial resolutions. These results will be presented and discussed together with an estimation of the average dose delivered to the phantom and the dependence of the image quality on the dose. Due to the heavy computation load required by the algebraic algorithms the reconstruction programs have been implemented to fully exploit the high calculation parallelism of Graphics Processing Units. An extended field of view pCT system is in an advanced construction stage. This apparatus will be able to reconstruct objects of the size of a human head making possible to characterize this pCT approach in a pre-clinical environment.

Published
2017

11. Medical research and multidisciplinary applications with laser-accelerated beams: The ELIMED netwotk at ELI-Beamlines

Author

Fabrizio Romano, Luigi Raffaele, Giacomo Cuttone, A. Anzalone, T Licciardello, Lorenzo Manti, Pietro Pisciotta, G.A.P. Cirrone, G. Korn, A. Tramontana, Valentina Scuderi, M. Carpinelli, Francesco Romano, Salvatore Tudisco, Daniele Margarone, F. M. Perozziello, C. Stancampiano, G. Candiano, Lorenzo Torrisi, Francesco Schillaci, Mario Maggiore, A. Musumarra, Tramontana, A, Anzalone, A, Candiano, G, Carpinelli, M, Cirrone, G, Cuttone, G, Korn, G, Licciardello, T, Maggiore, M, Manti, L, Margarone, D, Musumarra, A, Perozziello, F, Pisciotta, P, Raffaele, L, Romano, F, Stancampiano, C, Schillaci, F, Scuderi, V, Torrisi, L, Tudiscob, S, Cirrone, Gap, Manti, Lorenzo, Perozziello, Francesca Margaret, Raffaelee, L, Romano, Fp, and Tudisco, S.

Subjects
Physics, High energy, electron-driven), Models and simulation, Plasma diagnostic, business.industry, Models and simulations, Plasma diagnostics chargedparticle spectroscopy, Wake-field acceleration (laser-driven, electron-driven), Instrumentation, Mathematical Physics, Electrical engineering, Laser, Medical research, law.invention, Wake-field acceleration (laser-driven, Beamline, Multidisciplinary approach, law, Aerospace engineering, business, Beam (structure)
Abstract

Laser accelerated proton beams represent nowadays an attractive alternative to the conventional ones and they have been proposed in different research fields. In particular, the interest has been focused in the possibility of replacing conventional accelerating machines with laser-based accelerators in order to develop a new concept of hadrontherapy facilities, which could result more compact and less expensive. With this background the ELIMED (ELIMED: ELI-Beamlines MEDical applications) research project has been launched by LNS-INFN researchers (Laboratori Nazionali del Sud-Istituto Nazionale di Fisica Nucleare, Catania, IT) and ASCR-FZU researchers (Academy of Sciences of the Czech Republic-Fyzikalni ustar, Prague, Cz), within the pan-European ELI-Beamlines facility framework. Its main purposes are the demonstration of future applications in hadrontherapy of optically accelerated protons and the realization of a laser-accelerated ion transport beamline for multidisciplinary applications. Several challenges, starting from laser-target interaction and beam transport development, up to dosimetric and radiobiological issues, need to be overcome in order to reach the final goals. The design and the realization of a preliminary beam handling and dosimetric system and of an advanced spectrometer for high energy (multi-MeV) laser-accelerated ion beams will be shortly presented in this work.

Published
2014

12. A new Thomson Spectrometer for high energy laser-driven beams diagnostic

Author

C. De Martinis, Dario Giove, Josef Krasa, Lorenzo Torrisi, Francesco Schillaci, Mario Maggiore, Giacomo Cuttone, Pietro Pisciotta, G. Korn, A. Tramontana, Andriy Velyhan, J. Prokůpek, Fabrizio Romano, Valentina Scuderi, M. Carpinelli, M. Cutroneo, S. Cavallaro, G. Candiano, Daniele Margarone, G.A.P. Cirrone, Cirrone, G, Tramontan, A, Candiano, G, Carpinelli, M, Cavallaro, S, Cutroneo, M, Cuttone, G, De Martinis, C, Giove, D, Krasa, J, Korn, G, Maggiore, M, Margarone, D, Pisciotta, P, Prokupek, J, Romano, F, Schillaci, F, Scuderi, V, Torrisi, L, and Velyhan, A

Subjects
Physics, Spectrometer, business.industry, Heavy-ion detector, Detector, Data processing method, Data processing methods, Heavy-ion detectors, Plasma diagnostics - charged-particle spectroscopy, Wake-field acceleration (laser-driven electron-driven), Instrumentation, Mathematical Physics, Laser, law.invention, Ion, Optics, Deflection (physics), law, Electric field, business, Energy (signal processing), Beam (structure)
Abstract

Thomson Spectrometers (TPs) are widely used for beam diagnostic as they provide simultaneous information on charge over mass ratio, energy and momentum of detected ions. A new TP design has been realized at INFN-LNS within the LILIA (Laser Induced Light Ion Acceleration) and ELIMED (MEDical application at ELI-Beamlines) projects. This paper reports on the construction details of the TP and on its experimental tests performed at PALS laboratory in Prague, with the ASTERIX IV laser system. Reported data are obtained with polyethylene and polyvinyl alcohol solid targets, they have been compared with data obtained from other detectors. Consistency among results confirms the correct functioning of the new TP. The main features, characterizing the design, are a wide acceptance of the deflection sector and a tunability of the, partially overlapping, magnetic and electric fields that allow to resolve ions with energy up to about 40 MeV for protons.

Published
2014

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