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Your search keyword '"Helia O"' showing total 2 results
Start Over Author "Helia O" Publisher institute of organic chemistry & biochemistry
2 results on '"Helia O"'

1. Dependence of in vitro Enzymic Hydrolysis of Alkyl(2-benzoyloxyethyl)dimethylammonium Bromides on the Alkyl Length

Author

Emil Švajdlenka, Eva Olaszová, Helia O, Ivan Lacko, Pauliková I, and Ferdinand Devínský

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Hydrolysis, chemistry, Enzymic hydrolysis, Kinetics, Microsome, Choline, General Chemistry, Medicinal chemistry, Alkyl, In vitro, Benzoic acid
Abstract

Microsomal esterases were used in the study of the in vitro enzymic hydrolysis of the ester bond in alkyl(2-benzoyloxyethyl)dimethylammonium bromides. These compounds are potential "soft" disinfectants, easily biodegradable to nontoxic biologically inactive hydrolytic products, namely substituted choline and benzoic acid. Formation of the latter product was used to monitor the kinetics of the reaction. It has been found that the rate of enzymic hydrolysis is substantially influenced by different length of the alkyl chain on the ammonium nitrogen. At the same time, interspecies (rat-mouse) and interorgan (liver-kidney) variability has been observed.

Published
1998
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