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We tried to reproduce results measured in the wind tunnel experiment with a CFD simulation provided by numerical model PALM. A realistic buildings layout from the Prague-Dejvice quarter has been chosen as a testing domain because solid validation campaign for PALM simulation of Atmospheric Boundary Layer (ABL) over this quarter was documented in the past. The question of input data needed for such simulation and capability of the model to capture correctly the inlet profile and its turbulence structure provided by the wind-tunnel is discussed in the study. The PALM dynamical core contains a solver for the Navier-Stokes equations. By default, the model uses the Large Eddy Simulation (LES) approach in which the bulk of the turbulent motions is explicitly resolved. It is well validated tool for simulations of the complex air-flow within the real urban canopy and also within its reduced scale provided by wind tunnel experiments. However the computed flow field between the testing buildings did not correspond well to the measured wind velocity in some points. Different setting of the inlet boundary condition was tested but none of them gave completely developed turbulent flow generated by vortex generators and castellated barrier wall place at the entrance of the aerodynamic section of the wind tunnel.