1. Variably Scaled Kernels Improve Classification of Hormonally-Treated Patient-Derived Xenografts
- Author
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Cathrin Brisken, Stefano De Marchi, Francesco Marchetti, Fabio De Martino, and Marie Shamseddin
- Subjects
Support vector machine ,Treated patient ,hormones ,patient-derived xenografts ,Variably scaled kernels ,Hormone receptor ,Computer science ,Kernel (statistics) ,Classification methods ,Computational biology ,interpolation - Abstract
Little is known about the biological functions which are exerted by hormone receptors in physiological conditions. Here, we made use of the Mouse INtraDuctal (MIND) model, an innovative patient-derived xenograft (PDX) model, to characterize global gene expression changes, which are triggered by stimulation of dihydrotestosterone (DHT) and progesterone (P4) in vivo. Fast and clever mathematical tools are needed to analyze increasing numbers of complex datasets. We generated hormone receptor-specific list of genes which were then used to test the classification performance obtained by different machine-learning algorithms in the frame of our labelled PDXs RNAseq dataset. Next to other standard techniques, we consider the variably scaled kernel (VSK) setting in the framework of support vector machines. Our results show that mixed schemes obtained via VSKs can outperform standard classification methods in the considered task.
- Published
- 2020