1. Dynamic updating in DIAS-NIDDM and DIAS causal probabilistic networks
- Author
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Hovorka, Roman, Tudor, Romulus S., Southerden, David, Meeking, Darryl R., Andreassen, Steen, Hejlesen, Ole K., and Cavan, David R.
- Subjects
Blood sugar monitoring -- Models ,Diabetes -- Research ,Carbohydrate metabolism -- Models ,Biological sciences ,Business ,Computers ,Health care industry - Abstract
Diabetes advisory system (DIAS) is a decision support system, which has been developed to provide advice on the amount of insulin injected by subjects with insulin-dependent diabetes mellitus (IDDM). DIAS employs a temporal causal probabilistic network (CPN) to implement a stochastic model of carbohydrate metabolism. The CPN network has recently been extended to provide also advice to subjects with noninsulin-dependent diabetes mellitus (NIDDM). However, due to increased complexity and size of the extended CPN the calculations became unfeasible. The CPN network was, therefore, simplified and a novel approach employed to generate conditional probability tables. The principles of dynamic CPN's were adopted and, in combination with the method of conditioning, learning, and forecasting, were implemented in a time- and memory-efficient way. An evaluation using experimental data was carried out to compare the original and revised DIAS implementations employing data collected by patients with IDDM, and to assess the a posteriori identifiability of model parameters in patients with NIDDM. Index Terms - Bayesian networks, carbohydrate metabolism, causal probabilistic networks, diabetes, dynamic causal probabilistic networks, stochastic modeling.
- Published
- 1999