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Your search keyword '"Vivek K. Rajwanshi"' showing total 2 results
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2 results on '"Vivek K. Rajwanshi"'

1. Synthesis of 5'-Triphosphate Mimics (P3Ms) of 3'-Azido-3',5'-Dideoxythymidine and 3',5'-Dideoxy-5'-Difluoromethylenethymidine as HIV-1 Reverse Transcriptase Inhibitors

Author

Guangyi Wang, Marija Prhavc, Jennifer L. Brooks, Tiffany Hurd, P. Dan Cook, Vivek K. Rajwanshi, and Patrick Fagan

Subjects
Molecular Structure, Molecular Mimicry, Human immunodeficiency virus (HIV), General Medicine, medicine.disease_cause, Pyrophosphate, Biochemistry, Reverse transcriptase, HIV Reverse Transcriptase, chemistry.chemical_compound, Structure-Activity Relationship, chemistry, medicine, Genetics, Reverse Transcriptase Inhibitors, Thymine Nucleotides, Molecular Medicine, Nucleoside, Zidovudine, Dideoxynucleotides, Thymidine
Abstract

3'-Azido-3',5-dideoxythymidine 5'-phosphonate and 3',5'-dideoxy-5'-difluoromethylenethymidine 5'-phosphonate were prepared by multistep syntheses. The nucleoside 5'-phosphonates were converted to their triphosphates and triphosphate mimics (P3Ms) containing beta,gamma-difluoromethylene, beta,gamma-dichloromethylene, or beta,gamma-imodo by condensation with pyrophosphate or pyrophosphate mimics, respectively. Inhibition of HIV-1 reverse transcriptase by the nucleoside P3Ms is briefly discussed.

Published
2005
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2. Synthesis of 5,7-Dihydroxy-6-methoxy-2-(2-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one and Reassignment of Structure of Tamaridone1

Author

Aparna Bharadvaja, Subhash C. Jain, Vivek K. Rajwanshi, Ravindra Kumar, and S. Talwar

Subjects
Stereochemistry, Chemistry, Organic Chemistry, Benzopyran-4-one
Abstract

The proposed structure of a new flavone, tamaridone, isolated from Tamarix dioica Roxb is untenable on the basis of comparison with its synthetic sample. Its structure has been now revised to 5,7-dihydroxy-8-methoxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one by careful spectral studies.

Published
1997
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