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Low density Lipoprotein cholesterol)LDL-C) levels show a clear relationship with cardiovascular disease (CVD). Statins are first line agents to reduce LDL-C and CVD risk. However, combination lipid-lowering therapy is often required to achieve large reductions in LDL-C.Colesevelam HCl is a bile acid sequestrant (BAS), which reduces LDL-C by 16-22% in monotherapy and adds a further 12-14% reduction in LDL-C when combined with other lipid-lowering drugs. Like statins, colesevelam reduces C-reactive protein levels by 16% in monotherapy and additional 6% when added to statins. Colesevelam also reduced HbABile acid sequestrants reduce LDL-C and HbA

Intercultural pedagogies are increasingly seen as affording opportunities for students to share perspectives, understandings and knowledge. In the shift towards such pedagogies, ways that language is conceptualised and the interrelationship between language, culture and knowing are often underexplored. This paper reports on an auto-ethnographic study that explores our experience as teachers of extending intercultural pedagogies beyond the context of language learning in higher education. Drawing on Bakhtin’s (1981) The dialogic imagination: Four essays notion of dialogism and Derrida’s (1997) Of grammatology notion of translation, we describe and explain how our reflexive practice enables us to deepen our focus both on language, culture, and knowing as integral in creating and interpreting meaning, and the self. Refereed/Peer-reviewed

This paper investigates the exchange rate pass-through to producer prices in South African industries from 1970 to 2016. Empirical results from panel contemporaneous techniques indicate that exchan...

Background: Clinical trials are essential for the advancement of cancer treatments; however, participation by patients is suboptimal. Currently, there is a lack of synthesized qualitative review evidence on the patient experience of trial entry from which to further develop decision support. The aim of this review is to synthesise literature reporting experiences of participants when deciding to enrol in a cancer clinical trial in order to inform practice. Methods: A systematic review and meta-synthesis of qualitative studies were conducted to describe the experiences of adult cancer patients who decided to enrol in a clinical trial of an anti-cancer treatment. Results: Forty studies met eligibility criteria for inclusion. Three themes were identified representing the overarching domains of experience when deciding to enrol in a cancer trial: 1) need for trial information; (2) trepidation towards participation; and (3) justifying the decision. The process of deciding to enrol in a clinical trial is one marked by uncertainty, emotional distress and driven by the search for a cure. Conclusion: Findings from this review show that decision support modelled by shared decision-making and the quality of a shared decision needs to be accompanied by tailored or personalised psychosocial and supportive care. Although the decision process bears similarities to theoretical processes outlined in decision-making frameworks, there are a lack of supportive interventions for cancer patients that are adapted to the clinical trial context. Theory-based interventions are urgently required to support the specific needs of patients deciding whether to participate in cancer trials.

This research segmented the birding market attracted to South African national parks based on their behavioural involvement. The data were collected by means of a self-administrated electronic ques...

This article explores the issues raised by the publication of Flame in the Snow, the private correspondence of the South African writers Andre Brink and Ingrid Jonker. Events around the entry of th...

South Africa is a semi-arid country that increasingly relies on groundwater as a freshwater source for both socio-economic and environmental systems. Groundwater resources are, however, limited and...

The recent court judgment of Uzani Environmental Advocacy CC v BP Southern Africa (Pty) Ltd 2019 (5) SA 275 (GP) found BP Southern Africa (Pty) Ltd (BP) guilty of environmental offences. The Court ...

Rationale: Limited research is available on endurance horse riding participants. Purpose: This research identified different segments of these niche participants. Methods: Self-administered questio...

This study aimed to assess inflammatory levels in first year university students and to determine whether associations exist between pro-inflammatory biomarker levels and academic performance. Infl...

The melt quench technique was used to prepare phosphate-based glasses composed of ZnO–Li2O–Na2O–P2O5 which were activated with luminescent Dy3+ ions and doped with various concentrations of...

Orientation: Wine festivals and events not only attract visitors, but also play a vital role in creating exposure to regional wines and wineries, increasing regional wine sales and stimulat...

An association between attachment and academic performance appears to be consistently found in children; however, reports on such an association in adolescents are contradictory. This study aimed t...

ADAM: A Paper for Bachelors was published by the Central News Agency in Johannesburg from December 1920 to February 1922. The initial print run was 1 400 but by the third issue this had inc...