1. MR Three-Dimensional Molecular Imaging of Intramural Biomarkers with Targeted Nanoparticles
- Author
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Gregory M. Lanza, Dana R. Abendschein, Veronica Glattauer, Jerome A. Werkmeister, Samuel A. Wickline, Tillmann Cyrus, Thomas D. Harris, John A. M. Ramshaw, and Shelton D. Caruthers
- Subjects
Pathology ,medicine.medical_specialty ,Swine ,medicine.medical_treatment ,Integrin ,Balloon ,Extracellular matrix ,Imaging, Three-Dimensional ,Restenosis ,Angioplasty ,Image Processing, Computer-Assisted ,medicine ,Animals ,Radiology, Nuclear Medicine and imaging ,Vascular Patency ,Fluorocarbons ,Radiological and Ultrasound Technology ,biology ,medicine.diagnostic_test ,business.industry ,Muscle, Smooth ,Magnetic resonance imaging ,Integrin alphaVbeta3 ,medicine.disease ,Immunohistochemistry ,Extracellular Matrix ,Hydrocarbons, Brominated ,Nanostructures ,Carotid Arteries ,Collagen Type III ,Angiography ,biology.protein ,Emulsions ,Molecular imaging ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Magnetic Resonance Angiography - Abstract
In this study, porcine carotid arteries were subjected to balloon overstretch injury followed by local delivery of paramagnetic nanoparticles targeted to alphavbeta3-integrin expressed by smooth muscle cells or collagen III within the extracellular matrix. Carotid T1-weighted angiography and vascular imaging was performed at 1.5T. While MR angiograms were indistinguishable between control and targeted vessel segments, alphavbeta3-integrin-and collagen Ill-targeted nanoparticles spatially delineated patterns and volumes of stretch injury. In conclusion, MR molecular imaging with alphavbeta3-integrin or collagen Ill-targeted nanoparticles enables the non-invasive, three-dimensional characterization of arterial pathology unanticipated from routine angiography.
- Published
- 2006
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