1. Desmoarylcoumarin and episoyasapogenol B: two new compounds from Desmodium salicifolium (Poir.) DC (Fabaceae)
- Author
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Donkia, Aphalaine Pinchemell Tiombou, Tchegnitegni, Billy Toussie, Tsafack, Borice Tapondjou, Tchuenguem, Roland Tchuenteu, Ponou, Beaudelaire Kemvoufo, Teponno, Rémy Bertrand, Dzoyem, Jean Paul, Musharraf, Syed Ghulam, and Tapondjou, Léon Azefack
- Subjects
Organic Chemistry ,Plant Science ,Biochemistry ,Analytical Chemistry - Abstract
A new 3-arylcoumarin, 7-hydroxy-6-(1,1-dimethylallyl)-2′,5′-dihydroxy-4′-(3,3dimethylprenyl)-3-arylcoumarin (desmoarylcoumarin) 1, a previously unreported oleanane-type triterpenoid, 3β,22β,23-trihydroxyolean-12-en (episoyasapogenol B) 2, together with five known flavonoids including darbergioidin (3), isoferreirin (4), quercetin (5), vitexin (6), swertizin (7), and one carbohydrate, sucrose (8) were isolated from the methanolic extract of the roots of Desmodium salicifolium. Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D) and mass spectrometric (HRFAB-MS) data. The methanolic extract, EtOAc and n-BuOH fractions as well as some isolated compounds were assessed for their antibacterial and antioxidant activities. The EtOAc fraction exhibited moderate activity against Enterococcus faecalis with MIC value of 128 µg/mL. The methanolic extract and the EtOAc fraction displayed DPPH scavenging activity with EC50 values of 5.99 and 2.06 μg/mL, respectively. Compound 1 showed a moderate antibacterial activity against Enterococcus faecalis with a MIC of 16 µg/mL. It also showed moderate DPPH scavenging activity.
- Published
- 2023