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Human platelets play important roles in several physiologic and pathologic processes. Any defects in platelet number and function can lead to a variety of bleeding complications; platelet transfusions are commonly used to improve platelet count and hemostatic function in these cases. However, transfusions are complicated by the short storage life of donated platelets and contamination risks. Synthetic platelet substitutes can render efficient hemostasis while allowing advantages of large-scale preparation, minimum contamination risk via effective sterilization, longer shelf-life, no need for blood type matching, and reduced risks of biologic or pathologic side effects. Recent efforts in synthetic platelet design have additionally focused on applications including hemostasis, drug delivery, and targeted delivery of cancer therapeutics. In the present review, we summarize the advancement of platelet-inspired nanomedicine for artificial blood component, tumor research, and treatment of thrombi.

The concentrations of 12 heavy metals (Cr, Co, Ni, Cu, Zn, Ga, Mo, Sn, Sb, Tl, Pb, Bi) in the marine near‐shore sediment cores of the Yellow Sea, China were investigated. Core A sediments had significantly lower concentrations of heavy metals than those of both Cores B and C according to the Bonferronic multiple comparison method. Based on multivariate statistic approaches (factor analysis and cluster analysis), two factors were identified controlling the heavy metal variability in the sediments. The enrichment factor (EF) and geo‐accumulation index (I geo) indicated Sb contamination from three sediment cores in this study area.

A chiral complex, SalenZn(II) (S), was synthesized and characterized. Its coordination with imidazole derivatives and amino acid ester derivatives was studied by UV-vis spectrophotometric titrations and CD spectroscopy. The binding constants decreased in the order K (Im)>K (2-MeIm)>K (2-Et-4-MeIm)>K (N-MeIm) for imidazole derivatives, and K (AlaOMe)>K (PheOMe)>K (ValOMe) for amino acid ester derivatives with the same configuration and K D >K L for amino acid esters with different configuration. CD spectra can quantify the strength of SalenZn(II)-ligand interactions, giving results consistent with the magnitudes of the binding constants. Moreover the minimum energy conformations of the adducts were obtained by simulated annealing, and quantum chemical calculations were performed based on those conformations to explain experimental results at the molecular level.