1. The chemical constituents from Urtica fissa leaves
- Author
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Meng-Yue Wang, Yan Yang, Shang-Shang Wang, Xi-Yan Zhou, Shi-Xin Duan, and Xiao-Bo Li
- Subjects
Lipopolysaccharides ,China ,Ceramide ,Magnetic Resonance Spectroscopy ,Flavonoid ,Anti-Inflammatory Agents ,Pharmaceutical Science ,Nitric Oxide ,01 natural sciences ,Urtica fissa ,Analytical Chemistry ,Mice ,chemistry.chemical_compound ,Drug Discovery ,Ic50 values ,Animals ,Medicine ,Medicine, Chinese Traditional ,Urticaceae ,Pharmacology ,chemistry.chemical_classification ,Folk medicine ,biology ,Traditional medicine ,Plant Extracts ,Tumor Necrosis Factor-alpha ,010405 organic chemistry ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Organic Chemistry ,Glycoside ,General Medicine ,biology.organism_classification ,0104 chemical sciences ,Plant Leaves ,010404 medicinal & biomolecular chemistry ,RAW 264.7 Cells ,Complementary and alternative medicine ,chemistry ,Chemical constituents ,Molecular Medicine ,business - Abstract
A new ceramide urticamide (1), two new secolignans urticalactones I (2) and Ⅱ (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (4-19), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, 8, and 13 possessed the potent anti-inflammatory. They could inhibit the release of NO and TNF-α in lipopolysaccharide (LPS) stimulated RAW 264.7 cells, with IC50 values less than 4.0 μM.
- Published
- 2017
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