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Vortioxetine is a multimodal-acting antidepressant that provides improvements on cognitive function aside from antidepressants and anxiolytic effects. Vortioxetine has been found to be one of the most effective and best tolerated options for major depressive disorder (MDD) in head-to-head trials.The present review intends to gather the most relevant and pragmatic data of vortioxetine in MDD, specially focusing on new studies that emerged between 2015 and 2020.Vortioxetine is the first antidepressant that has shown improvements both in depression and cognitive symptoms, due to the unique multimodal mechanism of action that combine the 5-HT reuptake inhibition with modulations of other key pre- and post-synaptic 5-HT receptors (agonism of 5-HT

The literature is unclear regarding the appropriate medical and psychological treatment of intersexuality: people who have genital, gonadal, or chromosomal characteristics that are neither all female nor all male. Medical and psychosocial management of such individuals is being reevaluated. Congenital adrenal hyperplasia (CAH), the most common cause of intersexual development among genetic females, is an inherited disorder that leads to varying degrees of masculinization of the external genitalia while internal genitals (ovaries, Fallopian tubes, and uterus) are typically female. The purpose of this study was to explore self-perceptions of adult women who have CAH and the impact of the condition on their relationships, sexuality, gender identity, gender roles, and self-concept. In addition, their perceptions of medical treatment were examined. Five women with CAH chose to participate. Participants reported: (a) a sense of isolation and embarrassment about sharing information concerning their cond...