1. Management of high-risk HPV-positive women for detection of cervical (pre)cancer
- Author
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Lise M.A. De Strooper, Renske D.M. Steenbergen, Peter J.F. Snijders, Johannes Berkhof, Roosmarijn Luttmer, Chris J.L.M. Meijer, Daniëlle A.M. Heideman, Pathology, CCA - Biomarkers, and Epidemiology and Data Science
- Subjects
Oncology ,medicine.medical_specialty ,Genotyping Techniques ,Uterine Cervical Neoplasms ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Cytology ,Genetics ,medicine ,Humans ,030212 general & internal medicine ,Molecular Biology ,Genotyping ,Cyclin-Dependent Kinase Inhibitor p16 ,Gynecology ,Cervical cancer ,Colposcopy ,Human papillomavirus 16 ,Human papillomavirus 18 ,medicine.diagnostic_test ,business.industry ,Papillomavirus Infections ,Cancer ,DNA Methylation ,medicine.disease ,Triage ,3. Good health ,Ki-67 Antigen ,030220 oncology & carcinogenesis ,DNA, Viral ,DNA methylation ,Molecular Medicine ,Biomarker (medicine) ,Female ,business ,Precancerous Conditions ,Papanicolaou Test - Abstract
Primary HPV-testing has been shown to provide a superior detection of women at risk of cervical (pre)cancer compared to cytology-based screening. However, as most high-risk HPV infections are harmless, additional triage testing of HPV-positive women is necessary to identify those with cervical (pre)cancer. In this paper, we compare the performance, advantages and limitations of clinically relevant available triage strategies for HPV-positive women.Many different colposcopy triage strategies, comprising both microscopy-based and molecular (virus/host-related) markers, have been suggested: Pap cytology, p16/Ki-67 dual-stained cytology, HPV16/18 genotyping, viral DNA methylation and host cell DNA methylation. Literature search was limited to triage strategies that have achieved at least phase 2 of the five-phase framework for biomarker development and studies including large cohorts (≥100 hrHPV-positive women). Triage markers were stratified by sample type (cervical scrape, self-collected sample) and by study population (screening, non-attendee, referral). Expert commentary: At present, repeat Pap cytology and Pap cytology combined with HPV16/18 genotyping are the only triage strategies that have been robustly shown to be ready for implementation. Other strategies such as p16/Ki-67 dual-stained cytology and host cell DNA methylation analysis, with or without additional HPV16/18 genotyping, are attractive options for the near future.
- Published
- 2016