1. Sleep Disturbances in COPD are Associated with Heterogeneity of Airway Obstruction
- Author
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Stefania Principe, Federica Pennavaria, Marco Basile, Nicola Scichilone, Alida Benfante, Emilia Mazzuca, Pierpaolo Baiamonte, Basile M., Baiamonte P., Mazzuca E., Principe S., Pennavaria F., Benfante A., and Scichilone N.
- Subjects
sleep abnormalitie ,Male ,Sleep Wake Disorders ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pulmonary disease ,CASIS ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,Forced Expiratory Volume ,Oscillometry ,Surveys and Questionnaires ,Internal medicine ,medicine ,COPD ,Humans ,Sleep Wake Disorder ,Oximetry ,030212 general & internal medicine ,Respiratory system ,Oxyhemoglobin ,Aged ,IOS ,Sleep quality ,business.industry ,Middle Aged ,Airway obstruction ,medicine.disease ,Sleep in non-human animals ,Sleep abnormalities ,Residual Volume ,030228 respiratory system ,Oxyhemoglobins ,Cardiology ,Female ,business ,Human - Abstract
Individuals with Chronic Obstructive Pulmonary Disease (COPD) experience sleep disturbances due to the impact of respiratory symptoms on sleep quality. We explored whether sleep disturbances in COPD are linked to heterogeneity of airway constriction.The impact of breathing problems on sleep quality was measured in consecutive COPD outpatients with the COPD and Asthma Sleep Impact Scale (CASIS) questionnaire. Impulse oscillometry technique (IOS) was employed to assess heterogeneity of airway constriction. Subjects with a previous or concomitant diagnosis of asthma or obstructive sleep apnea (OSA) were excluded.Fifty COPD subjects (M/F 40/10; age: 71 +/- 8 yrs, Body Mass Index (BMI): 26.2 +/- 4.7 kg/m(2), Forced Expiratory Volume in the first second (FEV1): 65 +/- 25% predicted; mean +/- SD) were enrolled. The mean CASIS score was 36 +/- 3.3, and the R5-R20 value was 0.2 +/- 0.15 kPa s L-1. The CASIS score was significantly higher in subjects with increased R5-R20 (>0.07 kPa s L-1) (39 +/- 24; p = 0.02) compared to normal R5-R20 (21 +/- 17). When subjects were categorized on the basis of lung function in severely versus non severely obstructed (FEV1 50% predicted) or air trappers versus non air trappers (Residual Volume, RV >= or
- Published
- 2018