1. Serum S100A6, S100A8, S100A9 and S100A11 proteins in colorectal neoplasia: results of a single centre prospective study
- Author
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Jaroslava Vávrová, Darina Kohoutova, Paula Moravkova, and Jan Bures
- Subjects
Adenoma ,Adult ,Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Carcinogenesis ,Clinical Biochemistry ,Gene Expression ,Cell Cycle Proteins ,Enzyme-Linked Immunosorbent Assay ,Sensitivity and Specificity ,S100A9 ,S100 Calcium Binding Protein A6 ,S100A8 ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Biomarkers, Tumor ,medicine ,Calgranulin B ,Humans ,Calgranulin A ,In patient ,Prospective Studies ,Prospective cohort study ,Aged ,Cancer immunology ,business.industry ,S100 Proteins ,General Medicine ,Middle Aged ,Serum concentration ,Colorectal carcinogenesis ,Single centre ,030104 developmental biology ,Case-Control Studies ,030220 oncology & carcinogenesis ,Female ,Colorectal Neoplasms ,business - Abstract
S100 proteins are involved in biological events related to colorectal carcinogenesis. Aim of this prospective study was to assess serum concentration of S100A6, A8, A9 and A11 proteins in patients with colorectal neoplasia. Eighty-four subjects were enrolled: 20 controls (average risk population with normal findings on colonoscopy; 7 men, 13 women, age 23-74, mean 55 ± 14), 20 patients with non-advanced colorectal adenoma (non-AA, 10 men, 10 women, age 41-82, mean 62 ± 11), 22 with advanced colorectal adenoma (AA, 15 men, 7 women, age 49-80, mean 64 ± 8) and 22 with colorectal cancer (CRC, 12 men, 10 women, age 49-86, mean 69 ± 10). Peripheral venous blood was obtained. Serum S100 proteins were investigated by enzyme immunoassay technique. Serum S100A6 was significantly lower in CRC (mean 8530 ± 4743 ng/L)
- Published
- 2019
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