1. Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals
- Author
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Kazuhisa Miyashita, Mikio Arita, Nobuyuki Miyai, Miyoko Utsumi, Tatsuya Takeshita, Kazufumi Terada, and Maki Shiozaki
- Subjects
Adult ,Male ,medicine.medical_specialty ,Mean arterial pressure ,Systole ,Physiology ,Pulse Wave Analysis ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Vascular Stiffness ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,Albuminuria ,Humans ,Medicine ,Ankle Brachial Index ,Arterial Pressure ,Vascular Diseases ,030212 general & internal medicine ,Exercise ,Subclinical infection ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Blood pressure ,Creatinine ,Asymptomatic Diseases ,Exercise Test ,Arterial stiffness ,Cardiology ,business - Abstract
This study was designed to evaluate the possible association between an exaggerated blood pressure (BP) response to exercise and subclinical vascular impairment in normotensive individuals.The study participants consisted of 92 untreated normotensive men (aged 42 ± 9 years) without a history of cardiovascular disease or stroke. A graded exercise test was conducted using a bicycle ergometer, and the mean arterial pressure (MAP) during submaximal exercise was evaluated. The brachial-ankle pulse wave velocity (baPWV) was measured as an index of arterial stiffness. The second peak of radial systolic BP (SBP2) was used as an estimate of central BP. The albumin-to-creatinine ratio (ACR) values were determined as the mean of two nonconsecutive spot urine specimens.Compared with individuals with a normal response (MAP z-score+1.0,These results suggest that subclinical vascular impairment is associated with an exaggerated increase in BP during exercise even in the absence of clinical hypertension.
- Published
- 2020
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