1. Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture
- Author
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Degang Wu, Xintong Zhao, Xinggen Fang, Zhenbao Li, Chenlei Huang, Niansheng Lai, Jiaqiang Liu, Xuanzhi Wang, Dayong Xia, Jinlong Yuan, and Xiao-chun Jiang
- Subjects
medicine.medical_specialty ,Aneurysm morphology ,business.industry ,Irregular shape ,Hemodynamics ,medicine.disease ,030227 psychiatry ,Aneurysm rupture ,03 medical and health sciences ,Oscillatory shear ,0302 clinical medicine ,Aneurysm ,Internal medicine ,Morphological analysis ,cardiovascular system ,medicine ,Cardiology ,Size ratio ,cardiovascular diseases ,business ,030217 neurology & neurosurgery - Abstract
Objective Hemodynamic factors are thought to play important roles in the pathogenesis, progression, and rupture of cerebral aneurysms. Previous hemodynamic studies have been based on comparisons between post-ruptured and unruptured aneurysms. Nevertheless, changes of aneurysm morphology after rupture render these results unreliable. Moreover, pressure, age, gender, and the morphology of the parent artery also influence these results. Therefore, in the present study, we identified hemodynamic and morphological characteristics of aneurysms prior to rupture using twelve mirror aneurysms. Materials and methods From our database, we retrospectively analyzed twelve mirror aneurysms (MANs) prior to rupture. Each mirror aneurysm was divided into the prior to rupture or the unruptured group. Patient-specific models were reconstructed from three-dimensional (3D) images of all patients. Hemodynamic and morphological factors were analyzed and compared. Results Compared with the unruptured side of MANs, aneurysms prior to rupture were significantly larger and significantly more irregular in shape; they also had significantly higher aspect ratio (AR), size ratio (SR), undulation index (UI), ellipticity index (EI), percentage of low wall shear stress area (LSA) and significantly lower normal wall shear stress (NWSS). The oscillatory shear index (OSI) and nonsphericity index (NSI) in the aneurysms prior to rupture were non-significantly higher than those of the unruptured group. Conclusion MANs prior to rupture may be extremely useful models to assess the risk of aneurysm rupture. Larger size, irregular shape, higher AR, SR, UI, NI, and lower WSS may be associated with aneurysms at risk for rupture.
- Published
- 2020