1. Decreased dickkopf-1 levels in chronic lymphocytic leukemia and increased osteopontin levels in non-Hodgkin's lymphoma at initial diagnosis: Could they be playing roles in pathogenesis?
- Author
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Mehmet Sevki Uyanik, Umit Tapan, Ömer Nuri Pamuk, Muhammet Maden, and Gülsüm Emel Pamuk
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Chronic lymphocytic leukemia ,stomatognathic system ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,Odds Ratio ,medicine ,Humans ,Osteopontin ,Extranodal Involvement ,neoplasms ,Survival analysis ,Aged ,Neoplasm Staging ,Univariate analysis ,biology ,business.industry ,Lymphoma, Non-Hodgkin ,Case-control study ,Hematology ,Middle Aged ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Survival Analysis ,Lymphoma ,Non-Hodgkin's lymphoma ,ROC Curve ,Case-Control Studies ,Immunology ,biology.protein ,Intercellular Signaling Peptides and Proteins ,Female ,business - Abstract
Aims We determined plasma levels of dickkopf-1 (DKK-1) and osteopontin (OPN) which have roles in the Wnt pathway in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) patients and in healthy controls. We also tested whether DKK-1 and OPN levels could be of clinical or prognostic significance in CLL and NHL. Methods We included 36 CLL, 24 NHL patients, and 21 healthy controls. Patients' clinical and demographic features, treatment modalities, and response to treatment were recorded. DKK-1 and OPN levels in plasma obtained at initial diagnosis were determined with enzyme-linked immunosorbent assay. Results CLL patients had significantly lower DKK-1 levels than NHL and control groups (P levels, respectively, 0.048 and 0.017). OPN level was significantly higher in NHL group than in CLL and control groups (P values, 0.017 and
- Published
- 2014