1. A new indole alkaloid, antioxidant and antibacterial activities of crude extracts from Saccocalyx satureioides
- Author
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Hayat Kherkhache, Imane Benabdelaziz, Mokhtar Boualem Lahrech, Hamada Haba, Mokhtar Benalia, and Artur M. S. Silva
- Subjects
Indole test ,Antioxidant ,Traditional medicine ,Indole alkaloid ,biology ,010405 organic chemistry ,medicine.medical_treatment ,Organic Chemistry ,Ethyl acetate ,Saccocalyx ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,Glucoside ,medicine ,Lamiaceae ,Antibacterial activity - Abstract
The new acylated indole alkaloid glucoside indole-3-carboxylic acid-(6'-O-caffeoyl)-β-D-glucoside 1 has been isolated from the ethyl acetate (EtOAC) extract of Saccocalyx satureioides Coss. & Dur. (Lamiaceae) together with eight known secondary metabolites 2-9. Two indoles 2 and 3, five methylated flavone aglycones 4-8 and one monoterpene glucoside 9 were reported for the first time in the genus Saccocalyx. The structural elucidation of these compounds was accomplished by spectroscopic methods including 1 D (1H and 13C) and 2 D (COSY, HSQC and HMBC) NMR techniques, and mass spectrometry, and by comparison with literature data. Light petroleum, EtOAc, chloroform and n-butanol (n-BuOH) extracts of S. Satureioides were screened for their antioxidant activity using DPPH radical scavenging and β-carotene bleaching methods. The antibacterial activity of these extracts indicates that n-BuOH and EtOAc extracts possess the strongest activity.
- Published
- 2018
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