1. Influence of Thyroid Hormones on Erythropoiesis and Radiation Resistance in C 57 Black Mice
- Author
-
J. Netíková, Milan Pospíšil, Mikeska J, and B. Hošek
- Subjects
Male ,Thyroid Hormones ,medicine.medical_specialty ,Period (gene) ,Radiation Dosage ,Radiation Tolerance ,Mice ,Oral administration ,Internal medicine ,medicine ,Animals ,Erythropoiesis ,Peripheral blood cell ,Radiation resistance ,business.industry ,Thyroid ,General Medicine ,Blood Cell Count ,Mice, Inbred C57BL ,Thyroid (USP) ,medicine.anatomical_structure ,Endocrinology ,Thyroid hormones ,Bone marrow ,business - Abstract
Oral administration of dried thyroid gland to C57Bl adult male mice in a dose of 0.6 g per 100 g diet during 10 days increased the metabolic rate and stimulated the erythropoiesis. Three to six days after thyroid pretreatment the radiation resistance of the mice increased, as revealed by their 30-day survival and a higher recovery of peripheral blood cell counts. The period of increased resistance to radiation was correlated with the receding of hypermetabolic effects and with the increase of repopulating abilities of the bone marrow cells.
- Published
- 1980