1. Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinicopathological characteristics and prognostic factors
- Author
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Johan Vanhaecke, Thomas Tousseyn, Julie Morscio, Geert Verleden, Xavier Sagaert, Rita Van Damme-Lombaerts, Jacques Pirenne, Lieselot Brepoels, Daan Dierickx, Steffen Fieuws, Marleen Renard, Gregor Verhoef, Dirk Kuypers, Frederik Nevens, Christiane De Wolf-Peeters, and Iwona Wlodarska
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Adolescent ,Biopsy ,medicine.medical_treatment ,Population ,Single Center ,Gastroenterology ,Young Adult ,International Prognostic Index ,Risk Factors ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Child ,education ,Survival analysis ,Aged ,Retrospective Studies ,Aged, 80 and over ,education.field_of_study ,business.industry ,Incidence ,Incidence (epidemiology) ,Hematopoietic Stem Cell Transplantation ,Retrospective cohort study ,Immunosuppression ,Organ Transplantation ,Hematology ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Lymphoproliferative Disorders ,Lymphoma ,Surgery ,Treatment Outcome ,Oncology ,Child, Preschool ,Female ,business - Abstract
Hematopoietic stem cell and solid organ transplant recipients diagnosed with biopsy-confirmed posttransplant lymphoproliferative disorder (PTLD) at our institution from 1989 to 2010 were identified. Patient-, transplant- and disease-related characteristics, prognostic factors and outcome were collected and analyzed. One hundred and forty biopsy-proven cases of PTLD were included. Overall incidence in the transplant population was 2.12%, with heart transplant recipients carrying the highest risk. Most PTLDs were monomorphic (82%), with diffuse large B-cell lymphoma being the most frequent subtype. The majority of cases (70.7%) occurred > 1 year posttransplant, and 66% were Epstein-Barr virus positive. Following initial therapy the overall response rate was 68.5%. Three-year relapse-free and overall survivals were 59% and 49%, respectively. At last follow-up, 44% of the patients were alive. Multivariable analysis identified several classical lymphoma-specific poor prognostic factors for the different outcome measures. The value of the International Prognostic Index was confirmed in our analysis. ispartof: LEUKEMIA & LYMPHOMA vol:54 issue:11 pages:2433-2440 ispartof: location:United States status: published
- Published
- 2013
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