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30 results on '"Ma, Lena Q."'

29. New measures in 2021 to increase the quality and reputation of the Critical Review in Environmental Science and Technology (CREST) journal

Author

Lena Q. Ma, Frederic Coulon, Scott A. Bradford, Jörg Rinklebe, Albert L. Juhasz, Robert J. Letcher, Yong Sik Ok, Ma, Lena Q, Letcher, Robert J, Coulon, Frederic, Juhasz, Albert, Rinklebe, Jörg, Ok, Yong Sik, and Bradford, Scott

Subjects
Environmental Engineering, media_common.quotation_subject, Crest, Quality (business), Engineering ethics, Pollution, Waste Management and Disposal, Water Science and Technology, Reputation, media_common
Abstract

Since its first publication in 1970, the Critical Reviews in Environmental Science and Technology (CREST) journal has served as an international forum for the publication of comprehensive, critical...

Published
2021

30. Arsenic, lead, and cadmium bioaccessibility in contaminated soils: Measurements and validations

Author

Ping Xiang, Hong-Bo Li, Shi-Wei Li, Meng-Ya Li, Lena Q. Ma, Albert L. Juhasz, Jie Li, Di Zhao, Li, Hong-Bo, Li, Meng-Ya, Zhao, Di, Li, Jie, Li, Shi-Wei, Xiang, Ping, Juhasz, Albert L, and Ma, Lena Q

Subjects
Cadmium, Contaminated soils, Environmental Engineering, in vivo bioavailability, 0208 environmental biotechnology, chemistry.chemical_element, Heavy metals, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, Pollution, 020801 environmental engineering, Human health, chemistry, in vitro bioaccessibility, correlation, Environmental chemistry, Soil water, Environmental science, mouse and swine models, heavy metals, Waste Management and Disposal, Arsenic, 0105 earth and related environmental sciences, Water Science and Technology
Abstract

Refereed/Peer-reviewed Ingestion of metal-contaminated soils poses risks to human health. To accurately assess the risks, in vitro assays have been developed to measure metal bioaccessibility. However, they often differ considerably in gastrointestinal fluid components and assay parameters, leading to inconsistent bioaccessibility results. As such, in vitro assays need to be validated against in vivo bioassays based on in vivo-in vitro correlations (IVIVCs). To help researchers to select the best in vitro assay and increase the robustness of the IVIVCs, there is a need to review and compile existing data. In this review, we focus on three metals (As, Pb, and Cd), five common in vitro assays (SBRC, UBM, IVG, DIN, and PBET), and two in vivo bioassays (mouse and swine models). Specifically, we 1) discuss variations in metal bioaccessibility measurements among different in vitro assays, 2) identify the roles of major gastrointestinal fluid constitutes and assay parameters in affecting metal bioaccessibility, 3) summarize weaknesses associated with existing IVIVCs, and 4) establish new IVIVCs using pooled soil samples from different studies. In addition, future research directions are highlighted, including better understanding of the roles of gastrointestinal fluid components, improving in vitro assays to better correlate with in vivo bioassays, expanding bioaccessibility measurements using different in vitro assays, validation of IVIVCs using independent soils, assessing the reliability of in vitro assays in remediated soils, and addressing the mechanisms behind IVIVCs.

Published
2019

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