1. Oropharyngeal swallow physiology and swallowing-related quality of life in underweight patients with concomitant advanced chronic obstructive pulmonary disease
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Luca Paoletti, Kendrea L Garand, Theresa Hopkins-Rossabi, Bonnie Martin-Harris, and Charlie Strange
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Male ,swallowing impairment ,dysphagia ,Modified Barium Swallow ,Population ,Physiology ,International Journal of Chronic Obstructive Pulmonary Disease ,Pulmonary Disease, Chronic Obstructive ,Random Allocation ,03 medical and health sciences ,0302 clinical medicine ,Thinness ,underweight ,Swallowing ,Modified Barium Swallow Impairment Profile ,Activities of Daily Living ,otorhinolaryngologic diseases ,medicine ,Humans ,COPD ,Prospective Studies ,030212 general & internal medicine ,education ,Prospective cohort study ,Aged ,Aged, 80 and over ,education.field_of_study ,Hand Strength ,business.industry ,digestive, oral, and skin physiology ,Reproducibility of Results ,General Medicine ,Middle Aged ,medicine.disease ,Dysphagia ,Deglutition ,3. Good health ,MBSImP ,030228 respiratory system ,Clinical Trial Report ,Case-Control Studies ,Quality of Life ,Female ,medicine.symptom ,Underweight ,Deglutition Disorders ,business - Abstract
Kendrea L Garand,1 Charlie Strange,2 Luca Paoletti,2 Theresa Hopkins-Rossabi,3 Bonnie Martin-Harris3 1Department of Speech Pathology and Audiology, College of Allied Health Professions, University of South Alabama, Mobile, AL 36688, USA; 2Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA; 3Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL 60208, USA Background: Swallowing impairment (dysphagia) has been associated with COPD and may contribute to exacerbations of this chronic and progressive disease. Further, risk of mortality increases with concomitant presence of cachexia in the COPD population. The purpose of this prospective study was to depict oropharyngeal swallowing physiology in underweight patients with stable but advanced-stage COPD. Patients and methods: Ten underweight patients with stable but advanced COPD underwent a modified barium swallow study. Analysis of oropharyngeal swallowing function was completed using the standardized Modified Barium Swallow Impairment Profile and the Penetration–Aspiration Scale. Scores from the Dysphagia Handicap Index and 10-item Eating Assessment Tool were collected to assess patient perception of swallowing difficulty. Findings were compared to age- and sex-matched healthy controls. Results: Significantly higher MBSImP oral total scores (P=0.007) were observed in COPD patients compared to matched controls, but no difference was observed in pharyngeal total scores (P=0.105). Patients with COPD had significantly higher maximum PAS scores compared with controls (P=0.030). There was no significant difference in EAT-10 or DHI scores between patients with COPD and controls (P=0.41 and P=0.08, respectively). Conclusion: Underweight patients with severe but stable COPD present with dysphagia that may not be recognized by the patient. Further investigation is needed to elucidate the interaction between the respiratory–swallowing systems, how muscular weakness may contribute to swallowing impairment, and responsiveness to swallowing treatment. Keywords: COPD, swallowing impairment, MBSImP, dysphagia, underweight
- Published
- 2018
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