1. Zmat3 splices together p53-dependent tumor suppression
- Author
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Laura D. Attardi and Kathryn T. Bieging-Rolett
- Subjects
Zinc finger ,0303 health sciences ,Cancer Research ,Cas9 ,Biology ,Cell biology ,03 medical and health sciences ,0302 clinical medicine ,RNA interference ,030220 oncology & carcinogenesis ,Genetically Engineered Mouse ,RNA splicing ,Author’s Views ,Molecular Medicine ,CRISPR ,Gene ,Transcription factor ,030304 developmental biology - Abstract
The tumor protein p53 (TP53, best known as p53) transcription factor is a critical tumor suppressor, but those p53-inducible genes most important for tumor suppression have remained unclear. Using unbiased RNA interference and CRISPR (Clustered Regularly Interspersed Palindromic Repeats)/Cas9 (CRISPR-associated protein 9) screens, genetically engineered mouse models, human cancer genome analysis, and integrative eCLIP-sequencing and RNA-sequencing analyses, we reveal a new branch of p53-mediated tumor suppression involving the RNA splicing regulator Zinc finger Matrin-type 3, Zmat3.
- Published
- 2021
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